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Human immunoglobulin versus plasmapheresis in guillain-barre syndrome and myasthenia gravis: A meta-analysis

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Ortiz-Salas, Paola
Vélez van Meerbeke, Alberto Francisco
Galvis-Gomez, Camilo Alberto
Q, Jesús H. Rodriguez



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Lippincott Williams and Wilkins

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Objectives: To evaluate the efficacy and safety over a short time period of human intravenous immunoglobulin versus plasma exchange (PE) in the management of some autoimmune neurologic diseases. In addition, length of hospital stay and duration of ventilator support were compared. Methods: Randomized controlled trials and analytical observational studies of more than 10 cases were reviewed. Cochrane Neuromuscular Disease Group trials, MEDLINE, EMBASE, HINARI, and Ovid, were searched as data source. Reference lists were examined for further relevant articles. A random-effect model was used to derive a pooled risk ratio. Results: A total of 552 articles were found and 24 met the criteria for a studied population of 4657 cases: 14 articles were about Guillain-Barré syndrome and 10 of myasthenia gravis. No evidence was found to suggest that PE or intravenous immunoglobulin differed in terms of efficacy or safety to treat any of the 2 diseases. Hospital stay length and ventilatory support time are different in each illness; however, we found no statistical difference in either of the 2 treatments. Conclusions: There is no evidence for superiority in the efficacy or safety of immunoglobulin or plasmapheresis in the management of Guillain-Barré syndrome and myasthenia gravis. However, caution should be exercised in the interpretation of these results given the limitations in the quality of the evidence and the heterogeneity of the studies. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Palabras clave
Albumin , intravenous , Human immunoglobulin , Immunoglobulin , Acute kidney failure , Allergic reaction , Anemia , Article , Artificial ventilation , Body weight , Chill , Diarrhea , Disability , Drug efficacy , Drug safety , Dyspnea , Faintness , Fever , Guillain barre syndrome , Headache , Heart arrhythmia , Hematoma , Hematuria , Hemolytic anemia , Human , Hypertension , Hypertransaminasemia , Hypocalcemia , Hypotension , Length of stay , Meningism , Meta analysis , Muscle weakness , Myasthenia gravis , Nausea and vomiting , Phlebitis , Plasmapheresis , Pneumonia , Priority journal , Randomized controlled trial (topic) , Rash , Sensitivity analysis , Sepsis , Systematic review , Treatment outcome , Vasospasm , Vein thrombosis , Vertigo , Comparative study , Guillain-barre syndrome , Myasthenia gravis , Plasmapheresis , Procedures , Guillain-barre syndrome , Humans , Immunoglobulins , Myasthenia gravis , Plasmapheresis , Randomized controlled trials as topic , Treatment outcome , Adverse effects , Autoimmune neurologic diseases , Efficacy , Immunoglobulin , Plasma exchange
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