Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder
Título de la revista
Baune, Bernhard T.
ISSN de la revista
Título del volumen
Major depressive disorder (MDD) is a common but serious psychiatric disorder with significant levels of morbidity and mortality. Recent genome-wide association studies (GWAS) on common variants increase our understanding of MDD; however, the underlying genetic basis remains largely unknown. Many studies have been proposed to explore the genetics of complex diseases from a viewpoint of the "missing heritability" by considering low-frequency and rare variants, copy-number variations, and other types of genetic variants. Here we developed a novel computational and statistical strategy to investigate the "missing heritability" of MDD. We applied Hamming distance on common, low-frequency, and rare single-nucleotide polymorphism (SNP) sets to measure genetic distance between two individuals, and then built the multi-dimensional scaling (MDS) pictures. Whole-exome genotyping data from a Los Angeles Mexican-American cohort (203 MDD and 196 controls) and a European-ancestry cohort (473 MDD and 497 controls) were examined using our proposed methodology. MDS plots showed very significant separations between MDD cases and healthy controls for low-frequency SNP set (P value < 2.2e-16) and rare SNP set (P value = 7.681e-12). Our results suggested that low-frequency and rare variants may play more significant roles in the genetics of MDD. © 2018 The Author(s).
California , Controlled Study , European American , Genetic Analysis , Genetic Variability , Genotype , Hamming Distance , Heritability , Human , Major Clinical Study , Major Depression , Mexican American , Single Nucleotide Polymorphism , Statistical Analysis , Whole Exome Sequencing , Estudio controlado , Americana Europea
Controlled Study , European American , Hamming Distance , Genotype