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Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder

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dc.contributor.gruplacGENIUROSspa
dc.creatorYu, Chenglong
dc.creatorArcos-Burgos, Mauricio
dc.creatorBaune, Bernhard T.
dc.creatorArolt, Volker
dc.creatorDannlowski, Udo
dc.creatorWong, Ma-Li
dc.creatorLicinio, Julio
dc.creator.googleYu, Chenglongspa
dc.creator.googleArcos-Burgos, Mauriciospa
dc.creator.googleBaune, Bernhard T.spa
dc.creator.googleArolt, Volkerspa
dc.creator.googleDannlowski, Udospa
dc.creator.googleWong, Ma.-Lispa
dc.creator.googleLicinio, Juliospa
dc.date.accessioned2019-09-24T21:00:42Z
dc.date.available2019-09-24T21:00:42Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractMajor depressive disorder (MDD) is a common but serious psychiatric disorder with significant levels of morbidity and mortality. Recent genome-wide association studies (GWAS) on common variants increase our understanding of MDD; however, the underlying genetic basis remains largely unknown. Many studies have been proposed to explore the genetics of complex diseases from a viewpoint of the "missing heritability" by considering low-frequency and rare variants, copy-number variations, and other types of genetic variants. Here we developed a novel computational and statistical strategy to investigate the "missing heritability" of MDD. We applied Hamming distance on common, low-frequency, and rare single-nucleotide polymorphism (SNP) sets to measure genetic distance between two individuals, and then built the multi-dimensional scaling (MDS) pictures. Whole-exome genotyping data from a Los Angeles Mexican-American cohort (203 MDD and 196 controls) and a European-ancestry cohort (473 MDD and 497 controls) were examined using our proposed methodology. MDS plots showed very significant separations between MDD cases and healthy controls for low-frequency SNP set (P value < 2.2e-16) and rare SNP set (P value = 7.681e-12). Our results suggested that low-frequency and rare variants may play more significant roles in the genetics of MDD. © 2018 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1038/s41398-018-0117-7
dc.identifier.issn2158-3188
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20331
dc.language.isoengspa
dc.relation.citationTitleTranslational Psychiatry
dc.relation.citationVolumeVol. 8
dc.relation.ispartofTranslational Psychiatry, ISSN:2158-3188, Vol. 8 (2018)spa
dc.relation.urihttps://www.nature.com/articles/s41398-018-0117-7.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationKessler, R.C., Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States (1994) Results from the National Comorbidity Survey. Arch. Gen. Psychiatry, 51, pp. 8-19spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCaliforniaspa
dc.subjectControlled Studyspa
dc.subjectEuropean Americanspa
dc.subjectGenetic Analysisspa
dc.subjectGenetic Variabilityspa
dc.subjectGenotypespa
dc.subjectHamming Distancespa
dc.subjectHeritabilityspa
dc.subjectHumanspa
dc.subjectMajor Clinical Studyspa
dc.subjectMajor Depressionspa
dc.subjectMexican Americanspa
dc.subjectSingle Nucleotide Polymorphismspa
dc.subjectStatistical Analysisspa
dc.subjectWhole Exome Sequencingspa
dc.subjectEstudio controladospa
dc.subjectAmericana Europeaspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordControlled Studyspa
dc.subject.keywordEuropean Americanspa
dc.subject.keywordHamming Distancespa
dc.subject.keywordGenotypespa
dc.subject.lembDepresión mentalspa
dc.subject.lembVariación genéticaspa
dc.titleLow-frequency and rare variants may contribute to elucidate the genetics of major depressive disorderspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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