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Angina renal. Caracterización de las herramientas de predicción de lesión renal aguda en cuidado intensivo adultos

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dc.contributor.advisorZuñiga Rodriguez, Eduardo Alfonso
dc.contributor.advisorMolano González, Nicolás
dc.creatorCastellanos de la Hoz, Juan Camilo
dc.creatorGarcia Habeych, Jose Mauricio
dc.creator.degreeEspecialista en Nefrologíaspa
dc.creator.degreeLevelMaestría
dc.creator.degreetypeFull timespa
dc.date.accessioned2021-07-28T20:55:00Z
dc.date.available2021-07-28T20:55:00Z
dc.date.created2021-07-13
dc.descriptionIntroducción. La lesión renal aguda (LRA) se caracteriza por una disminución abrupta de la función renal que desencadena graves consecuencias a largo plazo. La predicción del desarrollo de LRA en la unidad de cuidados intensivos (UCI) es limitada. Por lo tanto, se caracterizaron tres herramientas de predicción para LRA. Metodología. Estudio observacional retrospectivo, en adultos ingresados a UCI. Excluyendo pacientes en terapia de reemplazo renal previo al ingreso, LRA en el momento del ingreso, antecedente de trasplante renal, remitidos desde otra UCI o estancia < 48 horas. Los datos se recogieron durante una semana después del ingreso a UCI y se aplicaron a las herramientas de angina renal (Cruz et al., Índice de angina renal (RAI) y AKIpredictor). La LRA se definió con la clasificación KDIGO. Resultados. Ingresaron 1625 pacientes a UCI y se incluyeron 490 pacientes. 160 (32,6%) pacientes presentaron LRA. El puntaje de Cruz et al. presentó una sensibilidad del 92,8% y una especificidad del 56,6%, con una razón de verosimilitud negativa (-LR) de 0,13. El RAI y AKIpredictor presentaron un área bajo la curva de 0,66 (IC 95% 0,6-0,73) y 0,66 (IC 95% 0,59-0,73) respectivamente, con una -LR de 0,73 (IC 95% 0,6-0,89) y 0,4 (IC del 95%:0,17-0,77) respectivamente. Conclusiones. La caracterización de las herramientas de angina renal mostró que su utilidad radica en determinar qué pacientes tienen bajo riesgo y requieren menos intervenciones para la prevención de la LRA.spa
dc.description.abstractIntroduction. Acute Kidney Injury (AKI) is characterized by an abrupt decrease in kidney function that triggers severe long term consequences after the event. Prediction of the development of AKI in the (ICU) is limited. Therefore, three prediction tools for AKI were characterized. Methodology. Retrospective observational study, developed from January 31 to September 30, 2020, in adults admitted to the ICU. Patients on renal replacement therapy prior to admission, AKI at the time of admission, history of kidney transplantation, referred from another ICU or a stay of < 48 hours were excluded. Data was collected for a week after admission to intensive care and applied to the renal angina tools (Cruz et al., renal angina index and AKIpredictor). AKI was defined with the KDIGO classification. Results. 1625 patients were admitted to the ICU, of which 490 patients were included. 160 (32.6%) patients presented AKI. The Cruz et al. score presented a sensitivity of 92.8% and specificity of 56.6%, with a negative likelihood ratio (-LR) of 0.13. The renal angina index and AKIpredictor presented an area under the curve of 0.66 (95% CI 0.6-0.73) and 0.66 (95% CI 0.59-0.73) respectively, with a -LR of 0.73 (95% CI 0.6-0.89) and 0.4 (95% CI 0.17-0.77) respectively. Conclusions. The characterization of renal angina tools showed that their usefulness lies in determining which patients are at low risk and require fewer interventions for the prevention of AKI.spa
dc.format.extent109 pp.spa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_31937
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/31937
dc.language.isospaspa
dc.publisherUniversidad del Rosario
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Nefrología
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
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dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectAnálisis de herramientas de predicción de Lesión Renal Aguda (LRA)spa
dc.subjectBiomarcadores para el diagnóstico de Lesión Renal Aguda (LRA)spa
dc.subjectAngina renal (Metodología clínica para estratificación de riesgo de LRA)spa
dc.subjectEstrategias de evolución de riesgos de LRA en pacientes internados en UCIspa
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.keywordAnalysis of Acute Kidney Injury (AKI) prediction toolsspa
dc.subject.keywordBiomarkers for the diagnosis of Acute Kidney Injury (AKI)spa
dc.subject.keywordRenal Angina (Clinical Methodology for AKI Risk Stratification)spa
dc.subject.keywordStrategies for the evolution of AKI risk in patients admitted to intensive carespa
dc.subject.keywordRisk evolution strategies for AKI in patients admitted to the intensive carespa
dc.titleAngina renal. Caracterización de las herramientas de predicción de lesión renal aguda en cuidado intensivo adultosspa
dc.title.TranslatedTitleRenal angina. Characterization of the tools prediction of acute kidney injury in intensive care adultsspa
dc.typemasterThesiseng
dc.type.documentRevisión sistemáticaspa
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTesis de maestríaspa
local.department.reportEscuela de Medicina y Ciencias de la Saludspa
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