Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Mongui, Alvaro; Perez-Leal, Oscar; Soto, Sara C.; Cortes, Jimena; Patarroyo, Manuel A.

Ítem

Solo Metadatos

Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

https://repository.urosario.edu.co/handle/10336/25940
https://doi.org/10.1016/j.bbrc.2006.10.082

Autores

Mongui, Alvaro

Perez-Leal, Oscar

Soto, Sara C.

Cortes, Jimena

Patarroyo, Manuel A.

Fecha

2006-12-22

Editor

Elsevier

Citations

Métricas alternativas

Abstract

Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein’s expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques.