Ítem
Solo Metadatos
Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein
Título de la revista
Autores
Mongui, Alvaro
Perez-Leal, Oscar
Soto, Sara C.
Cortes, Jimena
Patarroyo, Manuel A.
Fecha
2006-12-22
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Editor
Elsevier
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Resumen
Abstract
Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein’s expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques.
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Keywords
Malaria , Plasmodium vivax , Merozoite , MSP7 , Vaccine candidate