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Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

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dc.creatorde-la-Torre, Alejandraspa
dc.creatorPfaff, Alexander W.spa
dc.creatorGrigg, Michael E.spa
dc.creatorVillard, Odilespa
dc.creatorCandolfi, Ermannospa
dc.creatorGomez-Marin, Jorge E.spa
dc.date.accessioned2020-05-26T00:05:51Z
dc.date.available2020-05-26T00:05:51Z
dc.date.created2014spa
dc.description.abstractPurpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-?), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cyto.2014.03.005
dc.identifier.issn10960023
dc.identifier.issn10434666
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23832
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage31
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage23
dc.relation.citationTitleCytokine
dc.relation.citationVolumeVol. 68
dc.relation.ispartofCytokine, ISSN:10960023, 10434666, Vol.68, No.1 (2014); pp. 23-31spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84907432899&doi=10.1016%2fj.cyto.2014.03.005&partnerID=40&md5=e9b6b6fdb9198ab9893f41d7dff207c3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCytokinespa
dc.subject.keywordoculareng
dc.subject.keywordCytokinomespa
dc.subject.keywordEotaxinspa
dc.subject.keywordFibroblast growth factorspa
dc.subject.keywordGamma interferonspa
dc.subject.keywordGamma interferon inducible protein 10spa
dc.subject.keywordInterleukin 10spa
dc.subject.keywordInterleukin 13spa
dc.subject.keywordInterleukin 15spa
dc.subject.keywordInterleukin 17spa
dc.subject.keywordInterleukin 4spa
dc.subject.keywordInterleukin 5spa
dc.subject.keywordInterleukin 9spa
dc.subject.keywordMacrophage inflammatory protein 1alphaspa
dc.subject.keywordMacrophage inflammatory protein 1betaspa
dc.subject.keywordMonocyte chemotactic protein 1spa
dc.subject.keywordPlatelet derived growth factor bbspa
dc.subject.keywordPlatelet derived growth factor beta receptorspa
dc.subject.keywordRantesspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordVasculotropinspa
dc.subject.keywordCytokinespa
dc.subject.keywordSignal peptidespa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAqueous humorspa
dc.subject.keywordArticlespa
dc.subject.keywordCataract extractionspa
dc.subject.keywordClinical articlespa
dc.subject.keywordColombianspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease severityspa
dc.subject.keywordEthnicityspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordMalespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordRecurrent diseasespa
dc.subject.keywordRegulatory t lymphocytespa
dc.subject.keywordSerotypespa
dc.subject.keywordSymptomatologyspa
dc.subject.keywordTh1 cellspa
dc.subject.keywordTh17 cellspa
dc.subject.keywordTh2 cellspa
dc.subject.keywordToxoplasma gondiispa
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordUveitisspa
dc.subject.keywordVery elderlyspa
dc.subject.keywordCase control studyspa
dc.subject.keywordEyespa
dc.subject.keywordMetabolismspa
dc.subject.keywordProspective studyspa
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordAqueous humorspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordCytokinesspa
dc.subject.keywordEyespa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordIntercellular signaling peptides and proteinsspa
dc.subject.keywordMalespa
dc.subject.keywordProspective studiesspa
dc.subject.keywordToxoplasmosiseng
dc.subject.keywordColombiaspa
dc.subject.keywordIntraocular cytokinesspa
dc.subject.keywordTh2spa
dc.subject.keywordToxoplasma gondiispa
dc.subject.keywordUveitisspa
dc.titleOcular cytokinome is linked to clinical characteristics in ocular toxoplasmosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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