Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism

Anaya, Juan-Manuel; Correa Paula A.; Herrera, Monica; Eskdale, Joyce; Gallagher, Grant

Ítem

Solo Metadatos

Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism

https://repository.urosario.edu.co/handle/10336/27893

Autores

Anaya, Juan-Manuel

Correa Paula A.

Herrera, Monica

Eskdale, Joyce

Gallagher, Grant

Fecha

2002

Editor

The journal of rheumatology

Citations

Métricas alternativas

Abstract

Objective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6).