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Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism

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dc.creatorAnaya, Juan-Manuel
dc.creatorCorrea Paula A.spa
dc.creatorHerrera, Monicaspa
dc.creatorEskdale, Joycespa
dc.creatorGallagher, Grantspa
dc.date.accessioned2020-08-19T14:44:29Z
dc.date.available2020-08-19T14:44:29Z
dc.date.created2002spa
dc.description.abstractObjective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6).eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0315-162X
dc.identifier.issnEISSN: 1499-2752
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27893
dc.language.isoengspa
dc.publisherThe journal of rheumatologyspa
dc.relation.citationEndPage1876
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage1874
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 29
dc.relation.ispartofJournal of Rheumatology, ISSN: 0315-162X; EISSN: 1499-2752, Vol.29, No.9 ( September 2002); pp. 1874-1876spa
dc.relation.urihttps://www.jrheum.org/content/jrheum/29/9/1874.full.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceJournal of Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSjögren’s Syndromespa
dc.subject.keywordInterleukin 10spa
dc.subject.keywordAnti-Ro Antibodiesspa
dc.subject.keywordAnti-La Antibodiesspa
dc.subject.keywordRheumatoid Factorspa
dc.subject.keywordPolymorphism Geneticsspa
dc.titleInterleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphismspa
dc.title.TranslatedTitleLa interleucina 10 (IL-10) influye en la respuesta autoinmune en el síndrome de Sjögren primario y está relacionada con el polimorfismo del gen IL-10spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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