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HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis

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Duarte-Rey, Carolina
Pardo, Aryce L.
Rodríguez-Velosa, Yolima
Mantilla, Ruben D.
Anaya, Juan-Manuel
Rojas-Villarraga, Adriana



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Background: Autoimmune hepatitis (AIH) is a chronic liver disease to which different Human Leukocyte Antigens (HLA) have been associated, according to the ethnic/geographical group affected, age of presentation, prognosis, and serologic profile. Objective: To identify common HLA class II alleles contributing to susceptibility to AIH in Latin American population. Methods: The present study was held through a systematic review of the literature, followed by a meta-analysis of 694 cases and 1769 controls of all case-control studies that supplied enough information for odd ratio and 95% confidence interval calculation conducted to date in Latin America. Results: The serological group DQ2 was found to be risk factor for AIH, while DR5 and DQ3 were found to be protective factors in this population. At the allelic level, DQB1*02, DQB1*0603, DRB1*0405, and DRB1*1301, were found to be risk factors, while DRB1*1302 and DQB1*0301 alleles were protective factors. The physicochemical similarities and differences of critical amino acids encoding the peptide binding groove at pockets P1, P4, and P6 of these HLA molecules, elucidates their influence in the development of disease. Conclusion: The current study strengthens the HLA component of AIH in Latin America and its relationship to other populations around the world. © 2008 Elsevier B.V. All rights reserved.
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Amino acid , preschool , Hla antigen class 2 , autoimmune , Hla dq2 antigen , Hla dq3 antigen , Hla dqb1 antigen , Hla dr antigen , Hla dr5 antigen , Unclassified drug , Allele , Autoimmune hepatitis , Demography , Disease course , Disease predisposition , Gene frequency , Geographic distribution , Human , Prognosis , Protein binding , Review , Risk assessment , Risk factor , Serology , South and central america , Systematic review , Adult , Case-control studies , Child , Child , Female , Genetic predisposition to disease , Hepatitis , Histocompatibility antigens class ii , Histocompatibility testing , Humans , Latin america , Male , Young adult , Autoimmune diseases , Autoimmune hepatitis , Hla antigens , Latin america , Major histocompatibility complex , Meta-analysis
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