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HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis

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dc.creatorDuarte-Rey, Carolina
dc.creatorPardo, Aryce L.spa
dc.creatorRodríguez-Velosa, Yolimaspa
dc.creatorMantilla, Ruben D.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorRojas-Villarraga, Adriana
dc.date.accessioned2020-05-26T00:01:27Z
dc.date.available2020-05-26T00:01:27Z
dc.date.created2009spa
dc.description.abstractBackground: Autoimmune hepatitis (AIH) is a chronic liver disease to which different Human Leukocyte Antigens (HLA) have been associated, according to the ethnic/geographical group affected, age of presentation, prognosis, and serologic profile. Objective: To identify common HLA class II alleles contributing to susceptibility to AIH in Latin American population. Methods: The present study was held through a systematic review of the literature, followed by a meta-analysis of 694 cases and 1769 controls of all case-control studies that supplied enough information for odd ratio and 95% confidence interval calculation conducted to date in Latin America. Results: The serological group DQ2 was found to be risk factor for AIH, while DR5 and DQ3 were found to be protective factors in this population. At the allelic level, DQB1*02, DQB1*0603, DRB1*0405, and DRB1*1301, were found to be risk factors, while DRB1*1302 and DQB1*0301 alleles were protective factors. The physicochemical similarities and differences of critical amino acids encoding the peptide binding groove at pockets P1, P4, and P6 of these HLA molecules, elucidates their influence in the development of disease. Conclusion: The current study strengthens the HLA component of AIH in Latin America and its relationship to other populations around the world. © 2008 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2008.11.005
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23367
dc.language.isoengspa
dc.relation.citationEndPage331
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage325
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 8
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.8, No.4 (2009); pp. 325-331spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-60649105599&doi=10.1016%2fj.autrev.2008.11.005&partnerID=40&md5=ec994df5f9e71266a5b613c2d9d3b72dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acidspa
dc.subject.keywordpreschooleng
dc.subject.keywordHla antigen class 2spa
dc.subject.keywordautoimmuneeng
dc.subject.keywordHla dq2 antigenspa
dc.subject.keywordHla dq3 antigenspa
dc.subject.keywordHla dqb1 antigenspa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordHla dr5 antigenspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAllelespa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordDemographyspa
dc.subject.keywordDisease coursespa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGeographic distributionspa
dc.subject.keywordHumanspa
dc.subject.keywordPrognosisspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordReviewspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSerologyspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordAdultspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordChildspa
dc.subject.keywordChildeng
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHepatitiseng
dc.subject.keywordHistocompatibility antigens class iispa
dc.subject.keywordHistocompatibility testingspa
dc.subject.keywordHumansspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMalespa
dc.subject.keywordYoung adultspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordHla antigensspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMajor histocompatibility complexspa
dc.subject.keywordMeta-analysisspa
dc.titleHLA class II association with autoimmune hepatitis in Latin America: A meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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