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Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder

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dc.creatorCastro, Tarynspa
dc.creatorMateus, Heidi Elianaspa
dc.creatorFonseca Mendoza, Dora Janeth
dc.creatorForero, Diegospa
dc.creatorRestrepo Fernández, Carlos Martín
dc.creatorTalero Gutiérrez, Claudia
dc.creatorVélez van Meerbeke, Alberto Francisco
dc.creatorLaissue, Paul
dc.date.accessioned2020-05-25T23:57:23Z
dc.date.available2020-05-25T23:57:23Z
dc.date.created2013spa
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a common neurobehavioral pathology characterized by distinct degrees of inattention, hyperactivity and impulsivity. Although ADHD etiology remains elusive, the ADRA2A candidate gene underlies a particular interest, since it participates in the prefrontal cortex regulation of executive function. Three SNPs located on 5? and 3?UTR regions of the gene have been extensively explored but none of them have been definitely validated as a predisposition or a causative sequence variation. In this study, in order to determine whether ADRA2A non-synonymous sequence variants, resulting in biochemical modifications of the protein, are a common cause of the disease we sequenced the complete ADRA2A coding region in a panel of ADHD children of Colombian origin. We identified the c.1138 C>A (p.Arg380Arg) silent substitution. We conclude that ADRA2A non-synonymous sequence variants do not cause ADHD in our sample population. We cannot formerly discard a potential role of this gene during ADHD pathogenesis since only the coding region was analysed. We hope that these results will encourage further researchers to sequence the promoter and coding regions of ADRA2A in large panels of ADHD patients from distinct ethnical origins. © 2013 Springer-Verlag Italia.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s10072-013-1569-4
dc.identifier.issn15901874
dc.identifier.issn15903478
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22657
dc.language.isoengspa
dc.relation.citationEndPage2222
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage2219
dc.relation.citationTitleNeurological Sciences
dc.relation.citationVolumeVol. 34
dc.relation.ispartofNeurological Sciences, ISSN:15901874, 15903478, Vol.34, No.12 (2013); pp. 2219-2222spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84890567991&doi=10.1007%2fs10072-013-1569-4&partnerID=40&md5=44aba97cc5c484b240337269c376d0e3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlpha 2A adrenergic receptorspa
dc.subject.keywordAlpha 2a adrenergic receptor genespa
dc.subject.keywordArticlespa
dc.subject.keywordAttention deficit disorderspa
dc.subject.keywordChildspa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordGenespa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic codespa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPromoter regionspa
dc.subject.keywordSchool childspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordWild typespa
dc.subject.keywordAttention Deficit Disorder with Hyperactivityspa
dc.subject.keywordChildspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordReceptorseng
dc.subject.keywordSequence Analysiseng
dc.subject.keywordADHDspa
dc.subject.keywordADRA2Aspa
dc.subject.keywordAttention deficit hyperactivity disorderspa
dc.subject.keywordBehaviorspa
dc.subject.keywordGeneticsspa
dc.titleSequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorderspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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