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Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante

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dc.contributor.advisorCuello López, Javier Mauricio
dc.creatorCuello López, Mariluz
dc.creatorFidalgo Zapata, Ana
dc.creatorLópez Agudelo, Laura
dc.creatorCuello López, Javier Mauricio
dc.creator.degreeEspecialista en Epidemiología (en Convenio con el CES)
dc.creator.degreeEspecialista en Epidemiología
dc.creator.degreeLevelEspecialización
dc.creator.degreetypeFull time
dc.date.accessioned2023-11-08T13:10:13Z
dc.date.available2023-11-08T13:10:13Z
dc.date.created2023-10-31
dc.descriptionIntroducción: el cáncer de mama, es una enfermedad heterogénea, con diferentes grados de agresividad, que dependen de su expresión fenotípica, destacándose el comportamiento de los receptores hormonales y Her2, que contribuyen finalmente a la respuesta al tratamiento y pronóstico de la enfermedad. Métodos: el objetivo principal de este estudio analítico, retrospectivo de cohorte histórica fue evaluar el valor pronostico del receptor progesterona en pacientes diagnosticadas con cáncer de mama luminal manejadas con quimioterapia neoadyuvante. Resultados: en un tiempo de seguimiento de 7,5 años, se estudiaron 178 pacientes, en su mayoría con fenotipo ER+/PR- (79,2%), sin embargo, no se observaron diferencias estadísticamente significativas en estos grupos a excepción del índice de enfermedad residual RDBN en el análisis multivariado para la evaluación pronostica del receptor de progesterona. Conclusión: En pacientes con cáncer de mama subtipo luminal tratadas con quimioterapia neoadyuvante, el estado del receptor de progesterona no se asoció como factor pronóstico de supervivencia.
dc.description.abstractAbstract: breast cancer is a heterogeneous disease, with different degrees of aggressiveness, which depends on its phenotypic expression, highlighting the behavior of hormone receptors and Her2, which will ultimately contribute to the response to treatment and prognosis of the disease. Methods: The main objective of this analytical, retrospective historical cohort study was to evaluate the prognostic value of the progesterone receptor in patients diagnosed with luminal breast cancer managed with neoadjuvant chemotherapy. Results: in a follow-up time of 7.5 years, 178 patients were studied, mostly with ER+/PR- phenotype (79.2%), however, no statistically significant differences were observed in these, except for the index of RDBN residual disease in multivariate analysis for progesterone receptor prognostic assessment. Conclusion: In patients with luminal subtype breast cancer treated with neoadjuvant chemotherapy, progesterone receptor status was not associated as a prognostic factor for survival.
dc.format.extent61 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_41492
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/41492
dc.language.isospa
dc.publisherUniversidad del Rosario
dc.publisherUniversidad CES. Facultad de Medicina
dc.publisherUniversidad de CES. Facultad de medicina
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Epidemiología
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
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dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCáncer de mama
dc.subjectReceptor de progesterona
dc.subjectQuimioterapia neoadyuvante
dc.subject.keywordBreast Neoplasms
dc.subject.keywordProgesterone receptor
dc.subject.keywordNeoadjuvant chemotherapy
dc.titleEvaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
dc.title.TranslatedTitlePrognostic evaluation of the progesterone hormone receptor in patients with luminal breast cancer treated with neoadjuvant chemotherapy
dc.typebachelorThesis
dc.type.documentTrabajo de grado
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de grado
local.department.reportEscuela de Medicina y Ciencias de la Salud
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