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Autoimmune thyroid disease in euthyroid subjects

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dc.contributorAnaya, Juan-Manuel
dc.contributorRojas, Manuel
dc.contributorMonsalve, Diana M.
dc.contributorAcosta-Ampudia, Yeny
dc.contributorPacheco, Yovana
dc.contributorRodríguez Jiménez, Mónica
dc.contributor.advisorRamírez Santana, Heily Carolina
dc.contributor.advisorMolano González, Nicolás
dc.creatorRodríguez Velandia, Yhojan Alexis
dc.creator.degreeEspecialista en Epidemiología (en Convenio con el CES)spa
dc.date.accessioned2018-09-06T16:39:12Z
dc.date.available2018-09-06T16:39:12Z
dc.date.created2018-09-04
dc.date.issued2018
dc.description.abstractOBJECTIVE: To determine the prevalence of thyroid autoantibodies and the associated factors in euthyroid subjects. METHODS: In this study, 300 euthyroid subjects chosen by stratified sampling from an inception cohort of 1335 individuals were included. None of the subjects was under treatment. Thyroid function was evaluated by measuring serum levels of TSH (0.3-4.5 μIU / ml) and FT4 (5.2-12.7μg / dl). In addition, anti-peroxidase (TPOAbs), anti-thyroglobulin (TgAbs), and anti-TSH receptor (TrAbs) autoantibodies were evaluated together with other 23 autoantibodies and vitamin D levels. The analysis included sociodemographic, clinical, and environmental characteristics. Data were analyzed by chi-square (χ2), Kruskal-Wallis, Mann-Whitney and logistical regression tests. RESULTS: Thyroid autoimmunity was observed in 15.3% of the subjects (TPOAbs in 11.3% and TgAbs in 2%). In six individuals, both autoantibodies were positive. TrAbs were not detected in any individual. Familial thyroid disease (P = 0.021,  = 3.4 CI: 1.2 – 9.5), low libido (P = 0.013,  = 3.8 CI: 1.3 – 10.6), the presence of other ADs (P = 0.014,  = 10.8 CI: 1.6 – 72.9) were associated with thyroid autoantibodies. In addition, VitD insufficiency (P= 0.03), never smoke (P = 0.010,  = 6.9 CI: 1.6 – 30.4), drinking more than 4 cups of coffee (P = 0.036,  = 3.8 CI: 1.1 – 13.1), and higher number of years exposed to wood smoke (P = 0.04), were associated with thyroid autoantibodies. Similar the last analysis, the presence of TPOAbs was associated with familial thyroid disease (P = 0.003,  = 4.9 CI: 1.7 - 14.0), never smoke (P = 0.002,  = 5.7 CI: 1.4 - 21.0), drinking > 4 cups of coffee (P = 0.047,  = 3.6 CI: 1.1 - 13.1), low libido (P = 0.001,  = 5.7 CI: 2.0 - 16.3). In addition, the presence of SS-A / Ro52 (P = 0.009,  = 36.7 CI: 2.5 - 549.9), and Ku (P = 0.046,  = 10.2 CI: 1.1 - 100.7), also was related to these autoantibodies. Regarding TgAbs, the presence of African ancestry (P = 0.01,  = 10.5 CI: 1.7 – 63.2), SS-A / Ro52 (P = 0.03,  = 15.8 CI: 1.2 – 198.6), and CENP-B (P = 0.02,  = 31.2 CI: 1.8 – 565.9) was associated with TgAbs. CONCLUSIONS: Subclinical thyroid autoimmunity is not rare. Environmental, genetic, and immunological factors as well as ancestry are associated risk factors. These results will facilitate the implementation of screening strategies in order to provide timely diagnosis and treatment.eng
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dc.identifier.doihttps://doi.org/10.48713/10336_18449
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18449
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de medicinaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectEuthyroidismspa
dc.subjectAnti-peroxidase autoantibodiesspa
dc.subjectAnti-thyroglobulin autoantibodiesspa
dc.subjectAutoimmune thyroid diseasespa
dc.subject.ddcAnatomía humana, citología, histologíaspa
dc.subject.lembTiroidesspa
dc.subject.lembTiroglobulinaspa
dc.subject.lembAutoanticuerposspa
dc.titleAutoimmune thyroid disease in euthyroid subjectsspa
dc.typebachelorThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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