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Expression of the major and pro-oncogenic H3K9 lysine methyltransferase SETDB1 in non-small cell lung cancer

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dc.creatorCruz-Tapias, Paolaspa
dc.creatorZakharova, Vladaspa
dc.creatorPerez-Fernandez, Oscar Mspa
dc.creatorMantilla, Williamspa
dc.creatorRamírez Clavijo, Sandra Rocío
dc.creatorAit-Si-Ali, Slimanespa
dc.date.accessioned2020-05-26T00:03:54Z
dc.date.available2020-05-26T00:03:54Z
dc.date.created2019spa
dc.description.abstractSETDB1 is a key histone lysine methyltransferase involved in gene silencing. The SETDB1 gene is amplified in human lung cancer, where the protein plays a driver role. Here, we investigated the clinical significance of SETDB1 expression in the two major forms of human non-small cell lung carcinoma (NSCLC), i.e., adenocarcinoma (ADC) and squamous cell carcinoma (SCC), by combining a meta-analysis of transcriptomic datasets and a systematic review of the literature. A total of 1140 NSCLC patients and 952 controls were included in the association analyses. Our data revealed higher levels of SETDB1 mRNA in ADC (standardized mean difference, SMD: 0.88; 95% confidence interval, CI: 0.73–1.02; p less than 0.001) and SCC (SMD: 0.40; 95% CI: 0.13–0.66; p = 0.003) compared to non-cancerous tissues. For clinicopathological analyses, 2533 ADC and 903 SCC patients were included. Interestingly, SETDB1 mRNA level was increased in NSCLC patients who were current smokers compared to non-smokers (SMD: 0.26; 95% CI: 0.08–0.44; p = 0.004), and when comparing former smokers and non-smokers (p = 0.009). Furthermore, the area under the curve (AUC) given by the summary receiver operator characteristic curve (sROC) was 0.774 (Q = 0.713). Together, our findings suggest a strong foundation for further research to evaluate SETDB1 as a diagnostic biomarker and/or its potential use as a therapeutic target in NSCLC. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/cancers11081134
dc.identifier.issn20726694
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23638
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 8
dc.relation.citationTitleCancers
dc.relation.citationVolumeVol. 11
dc.relation.ispartofCancers, ISSN:20726694, Vol.11, No.8 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071090308&doi=10.3390%2fcancers11081134&partnerID=40&md5=908d6e3bc6c0319f5c508e96dfe7ce72spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHistone lysine methyltransferasespa
dc.subject.keywordMessenger rnaspa
dc.subject.keywordSetdb1 proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordFemalespa
dc.subject.keywordGenespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordLung adenocarcinomaspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordNon small cell lung cancerspa
dc.subject.keywordPathologyspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordSetdb1 genespa
dc.subject.keywordSmokingspa
dc.subject.keywordSquamous cell lung carcinomaspa
dc.subject.keywordTranscriptomicsspa
dc.subject.keywordLysine methyltransferasespa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordNon-small cell lung cancerspa
dc.subject.keywordSetdb1/kmt1espa
dc.titleExpression of the major and pro-oncogenic H3K9 lysine methyltransferase SETDB1 in non-small cell lung cancerspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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