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Immunogenetics of primary Sjögren's syndrome in Colombians

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorMantilla, Ruben D.spa
dc.creatorCorrea, Paula A.spa
dc.date.accessioned2020-08-19T14:44:13Z
dc.date.available2020-08-19T14:44:13Z
dc.date.created2005-04spa
dc.description.abstractObjective: Data concerning the immunogenetic characteristics of primary Sjögren’s syndrome (SS) in Latin-Americans are scarce. A research project centered on primary SS in Colombians was initiated in January 1996 to better define these characteristics.MethodsTAP, HLA, IL-10, and microsatellites on 6p21.3 genotyping was performed by polymerase chain reaction techniques. Immunohistochemistry for Bcl-2 antagonist/killer (Bak) was performed. Autoantibodies and serum level of cytokines (IL-10, TNF-?, IFN-?, IL-4, and IL-12p70) were determined by enzyme-linked immunosorbent assay.ResultsThe HLA-DRB1*0301-DQB1*0201 haplotype was associated with disease (OR = 4.3, 95% CI: 1.6 to 11.9, P = 0.002), with a more severe histopathologic picture, and with the presence of anti-Ro and anti-La antibodies. D6S439 microsatellite polymorphism was associated with primary SS in an HLA-independent manner. The most likely gene related to the D6S439 chromosomal location appears to be BAK-1, which codes for Bak protein, expressed in salivary gland’s infiltrate from patients with primary SS but not in controls. IL-10 and IFN-? concentrations were significantly higher in patients than in controls (P < 0.01). IL-10 correlated with titers of IgA rheumatoid factor, anti-Ro, and anti-La antibodies, and with the severity of lymphocytic infiltrate (r > 0.3, P < 0.04). Patients who produced high IL-10 levels had significantly more episodes of cutaneous vasculitis and a higher proportion the IL-10.G9 allele.ConclusionsThe HLA-DRB1*0301-DQB1*0201 haplotype and IL-10 participate in the histopathological progression of SS, autoantibody production, and clinical manifestations. Bak protein and its gene polymorphism may participate in the pathology and susceptibility of disease. HLA and cytokine (IL-10 and IFN-?) manipulation may be helpful in treating patients with primary SS.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.semarthrit.2004.11.008
dc.identifier.issnISSN: 0049-0172
dc.identifier.issnEISSN: 1532-866X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27846
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage743
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage735
dc.relation.citationTitleSeminars in Arthritis and Rheumatism
dc.relation.citationVolumeVol. 34
dc.relation.ispartofSeminars in Arthritis and Rheumatism, ISSN: 0049-0172;EISSN: 1532-866X, Vol.34, No.5 (2005); pp. 735-743spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0049017204002434spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceSeminars in Arthritis and Rheumatismspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSjögren’s syndromespa
dc.subject.keywordHLAspa
dc.subject.keywordBakcytokinesspa
dc.subject.keywordIL-10spa
dc.subject.keywordIFN-?spa
dc.subject.keywordGeneticsspa
dc.subject.keywordColombiaspa
dc.titleImmunogenetics of primary Sjögren's syndrome in Colombiansspa
dc.title.TranslatedTitleInmunogenética del síndrome de Sjögren primario en colombianosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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