Ítem
Acceso Abierto

Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies

Título de la revista
Autores
Cifuentes R.A.
Rojas-Villarraga A.
Anaya, Juan-Manuel

Cargando...
Miniatura
Archivos

Fecha
2011

Directores

ISSN de la revista
Título del volumen
Editor

Citations

Métricas alternativas

Resumen
Abstract
Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. © 2011 American Society for Histocompatibility and Immunogenetics.
Palabras clave
Keywords
HLA antigen class 2 , Type 1 , HLA DQB1 antigen , HLA DR antigen , Article , Caucasian , Diabetogenesis , Ethnicity , Gene frequency , Genetic association , Genetic risk , Haplotype , Hispanic , Human , Insulin dependent diabetes mellitus , Meta analysis , Nucleotide sequence , Priority journal , Protein function , Protein protein interaction , Alleles , Amino Acid Sequence , Computational Biology , Diabetes Mellitus , Epitopes , Haplotypes , Histocompatibility Antigens Class II , Humans , Latin America , Peptides , Protein Binding , Autoimmunity , HLA class II , Latin America , Meta-analysis , Type 1 diabetes
Citations
Colecciones