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Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies

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dc.creatorCifuentes R.A.spa
dc.creatorRojas-Villarraga A.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:10:15Z
dc.date.available2020-05-26T00:10:15Z
dc.date.created2011spa
dc.description.abstractConclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. © 2011 American Society for Histocompatibility and Immunogenetics.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2011.03.012
dc.identifier.issn1988859
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24220
dc.language.isoengspa
dc.relation.citationEndPage586
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage581
dc.relation.citationTitleHuman Immunology
dc.relation.citationVolumeVol. 72
dc.relation.ispartofHuman Immunology, ISSN:1988859, Vol.72, No.7 (2011); pp. 581-586spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79958271443&doi=10.1016%2fj.humimm.2011.03.012&partnerID=40&md5=fcac38dbaf85c0527715707fcd9a88f7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA antigen class 2spa
dc.subject.keywordType 1eng
dc.subject.keywordHLA DQB1 antigenspa
dc.subject.keywordHLA DR antigenspa
dc.subject.keywordArticlespa
dc.subject.keywordCaucasianspa
dc.subject.keywordDiabetogenesisspa
dc.subject.keywordEthnicityspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHispanicspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordAllelesspa
dc.subject.keywordAmino Acid Sequencespa
dc.subject.keywordComputational Biologyspa
dc.subject.keywordDiabetes Mellituseng
dc.subject.keywordEpitopesspa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHistocompatibility Antigens Class IIspa
dc.subject.keywordHumansspa
dc.subject.keywordLatin Americaspa
dc.subject.keywordPeptidesspa
dc.subject.keywordProtein Bindingspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordHLA class IIspa
dc.subject.keywordLatin Americaspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordType 1 diabetesspa
dc.titleHuman leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studiesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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