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Characterizing T?cell receptor ??variable gene in Aotus nancymaae owl monkey peripheral blood
| dc.creator | Guerrero, J.E. | spa |
| dc.creator | Pacheco, D. P. | spa |
| dc.creator | Suárez, C. F. | spa |
| dc.creator | Martínez, P. | spa |
| dc.creator | Aristizabal, F. | spa |
| dc.creator | Moncada, C. A. | spa |
| dc.creator | Patarroyo, M. E. | spa |
| dc.creator | Patarroyo, M. A. | spa |
| dc.date.accessioned | 2020-08-19T14:41:52Z | |
| dc.date.available | 2020-08-19T14:41:52Z | |
| dc.date.created | 2003-11-11 | spa |
| dc.description.abstract | Gd T lymphocytes have a heterodimeric complex formed by theassociation of g and d chains as receptor. Proliferation of this lymphocytepopulation has been observed, when infection by several pathogens such asMycobacterium tuberculosis and Plasmodium spp. occurs. The New WorldMonkey Aotus nancymaae has become a very good experimental model forthe immunological and physiopathological study of these infectious agents.The A. nancymaae g-variable region was characterized from peripheral bloodsamples by using cDNA and genomic DNA polymerase chain reactionamplification, DNA sequencing, and dot-blot hybridization techniques.Seventeen different T-cell receptor g-variable (TCRGV) sequences wereobtained. These sequences were distributed among TCRGV subsets 1, 2, or 3,according to human subset classification. Although no subset 4 amplificationwas obtained, this subset was detected by dot-blot hybridization. Thepresence of these 4 subsets resembles the behavior displayed by ‘gd-lowspecies’ (humans and mice), where high diversity among these lymphocytescan be observed. Homologies greater than 70% were found with respect tohumans. Sequence convergence between human and A. nancymaae subsets1 and 3 highlights Aotus as a promising model for studying these lymphocytefunctions. | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.doi | https://doi.org/10.1046/j.1399-0039.2003.00130.x | |
| dc.identifier.issn | ISSN: 0001-2815 | |
| dc.identifier.issn | EISSN: 1399-0039 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/27358 | |
| dc.language.iso | eng | spa |
| dc.publisher | John Wiley & Sons | spa |
| dc.relation.citationEndPage | 482 | |
| dc.relation.citationIssue | No. 6 | |
| dc.relation.citationStartPage | 472 | |
| dc.relation.citationTitle | HLA, Tissue Antigens | |
| dc.relation.citationVolume | Vol. 62 | |
| dc.relation.ispartof | HLA. Tissue Antigens, ISSN: 0001-2815 ; EISSN: 1399-0039, Vol.62, No.6 (Dec, 2003); pp. 472-482 | spa |
| dc.relation.uri | https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1399-0039.2003.00130.x | spa |
| dc.rights.accesRights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.acceso | Restringido (Acceso a grupos específicos) | spa |
| dc.source | HLA, Tissue Antigens | spa |
| dc.source.instname | instname:Universidad del Rosario | |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
| dc.subject.keyword | Aotus | spa |
| dc.subject.keyword | Evolution | spa |
| dc.subject.keyword | Gd T lymphocytes | spa |
| dc.subject.keyword | Platyrrhini | spa |
| dc.subject.keyword | T-cell recepto | spa |
| dc.title | Characterizing T?cell receptor ??variable gene in Aotus nancymaae owl monkey peripheral blood | spa |
| dc.title.TranslatedTitle | Caracterización del gen variable ? del receptor de células T en sangre periférica de mono búho Aotus nancymaae | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
