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Risk factors associated with pulmonary arterial hypertension in Colombian patients with systemic sclerosis: Review of the literature

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dc.creatorCoral-Alvarado P.spa
dc.creatorRojas-Villarraga A.spa
dc.creatorLatorre M.C.spa
dc.creatorMantilla R.D.spa
dc.creatorRestrepo J.F.spa
dc.creatorPardo A.L.spa
dc.creatorChalem P.spa
dc.creatorRondón F.spa
dc.creatorJáuregui E.spa
dc.creatorRueda J.C.spa
dc.creatorCañas C.spa
dc.creatorHincapie M.E.spa
dc.creatorPineda-Tamayo R.spa
dc.creatorAlvarez F.spa
dc.creatorIglesias-Gamarra A.spa
dc.creatorDiaz F.J.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:56:31Z
dc.date.available2020-05-25T23:56:31Z
dc.date.created2008spa
dc.description.abstractObjective. Considering the significant morbidity and mortality of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc) and the lack of precise information on disease in Latin America, we investigated the clinical and laboratory characteristics associated with PAH in Colombian patients with SSc and review the literature. Methods. This multicenter study included patients followed at 5 rheumatology units that were systematically assessed using a pretested questionnaire on clinical and immunological variables, focusing on PAH. Conditional logistic regression was employed to assess association between PAH and specific clinical characteristics. A systematic review of the literature was performed through electronic databases. Results. Of a total of 349 patients with SSc, 61 (17%) met the criteria for PAH. Pulmonary fibrosis [adjusted odds ratio (AOR) 7.37, 95% CI 3.67-14.81, p less than 0.0001], microstomia (AOR 3.3, 95% CI 1.70-6.28, p less than 0.0001), gastroesophageal reflux (AOR 2.41, 95% CI 1.31-4.43, p = 0.005), dysphagia (AOR 2.7, 95% CI 1.49-4.77, p = 0.001), hyperpigmentation (AOR 2.15, 95% CI 1.11-4.16, p = 0.02), and hypopigmentation (AOR 2.4, 95% CI 1.26-4.64, p = 0.008) were the most prevalent clinical characteristics associated with PAH, while anemia (AOR 5.4, 95% CI 1.98-14.93, p = 0.001) was observed as the unique laboratory risk factor. Association between subtypes of SSc and PAH was not observed. Significant differences in both clinical and laboratory data were observed among different series. Conclusion. PAH may be a frequent complication of SSc in the Colombian population regardless of disease subtype. The identified clinical and laboratory risk factors might assist earlier diagnosis and guide decisions on therapeutic interventions on this critical complication of SSc. The reasons underlying the reported divergences among patients from different ethnicities are not fully understood, but it is most likely that both genetic and environmental factors are responsible for them.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn14992752
dc.identifier.issn0315162X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22450
dc.language.isoengspa
dc.relation.citationEndPage250
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage244
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 35
dc.relation.ispartofJournal of Rheumatology, ISSN:14992752, 0315162X, Vol.35, No.2 (2008); pp. 244-250spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-39549115711&partnerID=40&md5=0c8c0117d96030b2e5451a1da0ca6805spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordsystemiceng
dc.subject.keywordAnemiaspa
dc.subject.keywordpulmonaryeng
dc.subject.keywordArticlespa
dc.subject.keywordColombiaspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordData basespa
dc.subject.keywordDysphagiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGastroesophageal refluxspa
dc.subject.keywordHumanspa
dc.subject.keywordHyperpigmentationspa
dc.subject.keywordHypopigmentationspa
dc.subject.keywordLogistic regression analysisspa
dc.subject.keywordLung fibrosisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMicrostomiaspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPulmonary hypertensionspa
dc.subject.keywordQuestionnairespa
dc.subject.keywordRisk factorspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGastroesophageal refluxspa
dc.subject.keywordHumansspa
dc.subject.keywordHypertensioneng
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordOdds ratiospa
dc.subject.keywordPulmonary fibrosisspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSclerodermaeng
dc.subject.keywordColombiaspa
dc.subject.keywordPulmonary arterial hypertensionspa
dc.subject.keywordSystemic sclerosisspa
dc.titleRisk factors associated with pulmonary arterial hypertension in Colombian patients with systemic sclerosis: Review of the literaturespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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