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Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults : The BrainFit study

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dc.creatorDomínguez-Sánchez, María Andrea
dc.creatorBustos-Cruz, Rosa H.
dc.creatorVelasco-Orjuela, Gina P
dc.creatorQuintero, Andrea P.
dc.creatorTordecilla Sanders, María Alejandra
dc.creatorCorrea Bautista, Jorge Enrique
dc.creatorTriana Reina, Héctor Reynaldo
dc.creatorGarcía-Hermoso, Antonio
dc.creatorGonzález Ruíz, Katherine
dc.creatorPeña-Gúzman, Carlos A.
dc.creatorHernández, Enrique
dc.creatorPeña-Ibagon, Jhonatan C
dc.creatorTéllez-T, Luis Andrés
dc.creatorIzquierdo, Mikel
dc.creatorRamírez-Vélez, Robinson
dc.creator.googleDomínguez-Sanchéz, María A.
dc.creator.googleBustos-Cruz, Rosa H.
dc.creator.googleVelasco-Orjuela, Gina P.
dc.creator.googleQuintero, Andrea P.
dc.creator.googleTordecilla-Sanders, Alejandra
dc.creator.googleCorrea-Bautista, Jorge E.
dc.creator.googleTriana-Reina, Héctor R.
dc.creator.googleGarcía-Hermoso, Antonio
dc.creator.googleGonzález-Ruíz, Katherine
dc.creator.googlePeña-Guzmán, Carlos A.
dc.creator.googleHernández, Enrique
dc.creator.googlePeña-Ibagon, Jhonatan C.
dc.creator.googleTéllez-T, Luis A.
dc.creator.googleIzquierdo, Mikel
dc.creator.googleRamírez-Vélez, Robinson
dc.date.accessioned2019-09-11T20:16:07Z
dc.date.available2019-09-11T20:16:07Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractThe purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18-30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m2) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of < 600 MET min/week for > 6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m2 were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85-95% maximum heart rate [HRmax] interspersed with 4 min of recovery at 75-85% HRmax) (n = 14), resistance training (12-15 repetitions per set, at 50-70% of one repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and resistance exercise (n = 13), or non-exercising control (n = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 2.5-76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3-2.3; p = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95% CI, 2.6-41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 12.3-53.4; p = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group (R2 = 0.345, p = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols. © 2018 Domínguez-Sanchéz, Bustos-Cruz, Velasco-Orjuela, Quintero, Tordecilla-Sanders, Correa-Bautista, Triana-Reina, García-Hermoso, González-Ruíz, Peña-Guzmán, Hernández, Peña-Ibagon, Téllez-T, Izquierdo and Ramírez-Vélez.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.3389/fphys.2018.00741
dc.identifier.issn1664-042X
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/20258
dc.language.isoengspa
dc.relation.citationTitleFrontiers in Physiology
dc.relation.citationVolumeVol. 9
dc.relation.ispartofFrontiers in Physiology, ISSN:1664-042X, Vol. 9 (2018)spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fphys.2018.00741/fullspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationAfzalpour, M.E., Chadorneshin, H.T., Foadoddini, M., Eivari, H.A., Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain (2015) Physiol. Behav, 147, pp. 78-83spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectBrain Derived Neurotrophic Factorspa
dc.subjectNeurotrophic Factorspa
dc.subjectNeurotrophin 3spa
dc.subjectNeurotrophin 4spa
dc.subjectBody Compositionspa
dc.subjectBody Massspa
dc.subjectCohort Analysisspa
dc.subjectControlled Studyspa
dc.subjectDisease Associationspa
dc.subjectEnergy Expenditurespa
dc.subjectExercise Intensityspa
dc.subjectHeart Ratespa
dc.subjectHumanspa
dc.subjectIntervention Studyspa
dc.subjectMajor Clinical Studyspa
dc.subjectMalespa
dc.subjectObesityspa
dc.subjectPhysical Inactivityspa
dc.subjectPhysical Performancespa
dc.subjectRandomized Controlled Trialspa
dc.subjectResistance Trainingspa
dc.subjectWaist Circumferencespa
dc.subjectFactor neurotróficospa
dc.subjectFactor neurotrófico derivado del cerebrospa
dc.subjectNeurotrofina 3spa
dc.subjectNeurotrofina 4spa
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.lembEstado físicospa
dc.subject.lembEjercicio físicospa
dc.subject.lembMente y cuerpospa
dc.titleAcute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults : The BrainFit studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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