Ítem
Acceso Abierto
PAPP-A y β-hCG libre en el primer trimestre y el riesgo de aborto o mortinato: revisión sistemática
| dc.contributor.advisor | Herrera Méndez, Emiliano Mauricio | |
| dc.contributor.advisor | Ibáñez Pinilla, Milcíades | |
| dc.creator | Botero Builes, Diana Shirley | |
| dc.creator.degree | Especialista en Medicina Materno-Fetal | |
| dc.creator.degreeLevel | Especialización | |
| dc.date.accessioned | 2025-03-26T21:07:19Z | |
| dc.date.available | 2025-03-26T21:07:19Z | |
| dc.date.created | 2025-03-26 | |
| dc.description | Los biomarcadores (PPAP-A y β-hCG libre) reflejan la función fetoplacentaria endocrina y endotelial. Niveles bajos de PAPP-A (<0,4 MoM) o β-hCG libre (<0,5 MoM) se han asociado con un incremento en la frecuencia de desenlaces obstétricos adversos. Objetivo: Evaluar la capacidad predictiva de PAPP-A y la fracción libre de β-hCG como marcadores séricos del primer trimestre para evaluar el riesgo de aborto o mortinato. Se realizó una búsqueda sistemática en las bases electrónicas (01/01/2014-30/04/2024), para estudios que incluían gestantes con valores séricos conocidos de PAPP-A y/o β-hCG libre, que reportaron como desenlaces obstétricos adversos aborto o mortinato. Los artículos se analizaron utilizando herramientas que permitieron establecer la calidad de estos de acuerdo con el diseño de los estudios (PROBAST). Se identificaron 450 reportes en bases de datos y se seleccionaron 9 estudios que evaluaron los niveles bajos de PAPP-A y β-hCG en los desenlaces aborto y mortinato. Los estudios sugieren que niveles bajos de estos marcadores se asocian con aborto y mortinato, sin embargo, el rendimiento y la capacidad predictiva no fueron estadísticamente significativos en todos los estudios. Los niveles bajos de PAPP-A y β-hCG libre han sido utilizadas para el pronóstico de aneuploidías y trastornos de placentación, sin embargo, no parecen ser útiles para predecir el riesgo de aborto o mortinato. | |
| dc.description.abstract | Biomarkers (PPAP-A and free β-hCG) reflect endothelial and fetoplacental function. Low levels of PAPP-A (<0.4 MoM) or free β-hCG (<0.5 MoM) have been associated with an increased frequency of adverse obstetric outcomes. Objective: To evaluate the predictive capacity of PAPP-A and free β-hCG as first trimester serum markers to assess the risk of miscarriage or stillbirth. A systematic search was performed in electronic databases (2014 to April 2024) for studies that included pregnant women with known serum values of PAPP-A and/or free β-hCG, who reported miscarriage or stillbirth as adverse obstetric outcomes. Articles were analyzed using tools that allowed the quality of these to be established according to the design of the studies (PROBAST). 450 Reports were identified in databases and 9 studies were selected that evaluated low levels of PAPP-A and β-hCG in abortion and stillbirth outcomes. Studies suggest that low levels of these markers are associated with abortion and stillbirth, however, performance and predictive ability were not statistically significant in all studies. Low levels of PAPP-A and free β-hCG have been used for the prognosis of aneuploidies and placentation disorders, however, they do not seem to be useful for predicting the risk of abortion or stillbirth. | |
| dc.format.extent | 55 pp | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.doi | https://doi.org/10.48713/10336_45161 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/45161 | |
| dc.language.iso | spa | |
| dc.publisher | Universidad del Rosario | |
| dc.publisher.department | Escuela de Medicina y Ciencias de la Salud | |
| dc.publisher.program | Especialización en Medicina Materno-Fetal | |
| dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
| dc.rights.accesRights | info:eu-repo/semantics/openAccess | |
| dc.rights.acceso | Abierto (Texto Completo) | |
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| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
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| dc.source.instname | instname:Universidad del Rosario | |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
| dc.subject | Resultados adversos del embarazo | |
| dc.subject | Primer trimestre | |
| dc.subject | Fracción libre β-Gonadotropina coriónica humana | |
| dc.subject | Proteína plasmática A asociada al embarazo | |
| dc.subject | Aborto | |
| dc.subject | Óbito | |
| dc.subject.keyword | Adverse pregnancy outcomes | |
| dc.subject.keyword | First trimester | |
| dc.subject.keyword | Free fraction β-Human chorionic gonadotropin | |
| dc.subject.keyword | Pregnancy-associated plasma protein a | |
| dc.subject.keyword | Abortion | |
| dc.subject.keyword | Stillbirth | |
| dc.title | PAPP-A y β-hCG libre en el primer trimestre y el riesgo de aborto o mortinato: revisión sistemática | |
| dc.title.TranslatedTitle | First-trimester papp-a and free b-hcg and the risk of miscarriage or stillbirth: a systematic review | |
| dc.type | masterThesis | |
| dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | |
| dc.type.spa | Trabajo de grado | |
| local.department.report | Escuela de Medicina y Ciencias de la Salud | |
| local.regiones | Bogotá |
