Ítem
Acceso Abierto
Adalimumab Monotherapy or Combination Therapy With Methotrexate in Paediatric Uveitis
Título de la revista
Autores
Fabiani, Claudia
Cantarini, Luca
Tosi, Gian Marco
Frediani, Bruno
Hussein Amin, Rana
La Torre, Francesco
Gupta, Vishali
Hegazy,Mohamed Tharwat
Murthy, Kalpana Babu
Lopalco, Giuseppe
Fecha
2025-01-01
Directores
ISSN de la revista
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Editor
John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists
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Abstract
Background: The study objective was to compare the effectiveness of adalimumab (ADA) in monotherapy and in combination with methotrexate (MTX) for paediatric noninfectious uveitis (NIU). Methods: Registry-based observational study. Children receiving ADA for active uveitis were divided into the ADA monotherapy group (group 1) and the ADA plus MTX combination group (group 2). Results Eighty four children were enrolled (146 eyes): 22 in group 1 (26.2%) and 62 in group 2 (73.8%). ADA effectiveness was complete in 48 children (57.1%), partial in 23 (27.4%) and absent in 4 (5.3%), without any differences across the groups (p?=?0.89). Fewer relapses per 100 PY occurred after ADA treatment both in group 1 (280.0 vs. 23.0, p?=?0.005) and in group 2 (297.9 vs. 86.0, p?<?0.001). The final BCVA was similar between groups 1 and 2 [median 1.0 (IQR 0.3) and 1.0 (IQR 0.3), respectively, p?=?0.55]. A statistically significant steroid-sparing effect was observed in the entire cohort and in group 2 at the 6-month (p?=?0.01 and p?=?0.01), 12-month (p?=?0.02 and p?=?0.02), and last follow-up (p?=?0.045 and p?=?0.045). The estimated ADA retention rate was 97.1% at 12?months, 87.7% at 24?months, and 82.6% at 36?months, without a statistically significant difference among the groups (p?=?0.77). Conclusions: ADA monotherapy could be equally effective as its combination with MTX in both preventing uveitis relapses and preserving visual acuity in paediatric NIU, with comparable retention rates over 36?months of treatment. The steroid-sparing effect of ADA monotherapy warrants further extensive evaluation to define its optimal placement in the therapeutic strategy for paediatric NIU.
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Keywords
Oftalmología , Adalimumab , Methotrexate , Monotherapy , Noninfectious uveitis , Paediatric ophthalmology
