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Evaluation of the antigenicity of universal epitopes from PvDBPII in individuals exposed to Plasmodium vivax malaria

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dc.creatorMartinez, Paolaspa
dc.creatorLopez, Carolinaspa
dc.creatorSaravia, Carolinaspa
dc.creatorVanegas, Magnoliaspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-25T23:57:03Z
dc.date.available2020-05-25T23:57:03Z
dc.date.created2010spa
dc.description.abstractThe Duffy-binding protein (PvDBP) mediates invasion of reticulocytes by the malaria parasite Plasmodium vivax. PvDBP has been recognized as a good vaccine candidate due to its ability to induce antibody responses capable of inhibiting target cell invasion after natural infections. For the development of subunit-based vaccines, it is important to identify universal epitopes that could be presented by different HLA-DR alleles to induce effective cellular and humoral immune responses. In this study, the antigenicity of universal epitopes from PvDBPII was evaluated by stimulating peripheral blood mononuclear cells (PBMCs) isolated from individuals with different degrees of P. vivax malaria exposure and distinct HLA-DR alleles. Peptides 1635 and 1638 induced lymphoproliferation and stimulated the production of IL-6 and IFN-?. The results suggest that conserved peptides binding with high activity to red blood cells and with known affinity to HLA-DR proteins could be good components for a P. vivax vaccine. © 2010 Institut Pasteur.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.micinf.2010.08.007
dc.identifier.issn12864579
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22594
dc.language.isoengspa
dc.relation.citationEndPage1197
dc.relation.citationIssueNo. 14-15
dc.relation.citationStartPage1188
dc.relation.citationTitleMicrobes and Infection
dc.relation.citationVolumeVol. 12
dc.relation.ispartofMicrobes and Infection, ISSN:12864579, Vol.12, No.14-15 (2010); pp. 1188-1197spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78649826770&doi=10.1016%2fj.micinf.2010.08.007&partnerID=40&md5=81d471a7ac981aa76dabe3413df30221spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDuffy binding proteinspa
dc.subject.keywordMononucleareng
dc.subject.keywordGamma interferonspa
dc.subject.keywordHLA DR antigenspa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordPeptide derivativespa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAllelespa
dc.subject.keywordAntigenicityspa
dc.subject.keywordArticlespa
dc.subject.keywordBinding affinityspa
dc.subject.keywordCell isolationspa
dc.subject.keywordCell stimulationspa
dc.subject.keywordClinical articlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordHumanspa
dc.subject.keywordLymphocyte proliferationspa
dc.subject.keywordPeripheral blood mononuclear cellspa
dc.subject.keywordPlasmodium vivax malariaspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAntigenseng
dc.subject.keywordCell Proliferationspa
dc.subject.keywordEpitopesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordInterferon-gammaspa
dc.subject.keywordInterleukin-6spa
dc.subject.keywordLeukocyteseng
dc.subject.keywordMalariaeng
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtozoan Proteinsspa
dc.subject.keywordReceptorseng
dc.subject.keywordYoung Adultspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordCytokinesspa
dc.subject.keywordDuffy-binding proteinspa
dc.subject.keywordPeptide vaccinesspa
dc.subject.keywordPlasmodium vivaxspa
dc.titleEvaluation of the antigenicity of universal epitopes from PvDBPII in individuals exposed to Plasmodium vivax malariaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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