Ítem
Acceso Abierto

The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease

Mostrar el registro sencillo de la publicación
dc.creatorTorres-Berrio A.spa
dc.creatorNava Mesa, Mauricio Orlandospa
dc.date.accessioned2020-05-25T23:58:34Z
dc.date.available2020-05-25T23:58:34Z
dc.date.created2019spa
dc.description.abstractCognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of post-traumatic stress disorder (PTSD) and Alzheimer's disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, stress response also involves the activation of the opioid system in brain regions associated with stress regulation and memory processing. In this context, it is possible that stress-induced memory disorders may be attributed to alterations in the interaction between the neuroendocrine stress system and the opioid system. In this review, we: (1) describe the effects of acute and chronic stress on memory, and the modulatory role of the opioid system, (2) discuss the contribution of the opioid system to the pathophysiology of PTSD and AD, and (3) present evidence of current and potential therapies that target the opioid receptors to treat PTSD- and AD-associated symptoms. © 2018 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.pnpbp.2018.08.011
dc.identifier.issn2785846
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22887
dc.language.isoengspa
dc.publisherElsevier Inc.spa
dc.relation.citationEndPage338
dc.relation.citationStartPage327
dc.relation.citationTitleProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.relation.citationVolumeVol. 88
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatry, ISSN:2785846, Vol.88,(2019); pp. 327-338spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85051957562&doi=10.1016%2fj.pnpbp.2018.08.011&partnerID=40&md5=0f680a249f5e54f46cb578134872c556spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordOpiatespa
dc.subject.keywordpsychologicaleng
dc.subject.keywordOpiate receptorspa
dc.subject.keywordOpiate peptidespa
dc.subject.keywordAcute stressspa
dc.subject.keywordAdrenergic systemspa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordBrain regionspa
dc.subject.keywordChronic stressspa
dc.subject.keywordCognitionspa
dc.subject.keywordEmotional disorderspa
dc.subject.keywordHumanspa
dc.subject.keywordHypothalamus hypophysis adrenal systemspa
dc.subject.keywordMemory disorderspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPosttraumatic stress disorderspa
dc.subject.keywordReviewspa
dc.subject.keywordStressspa
dc.subject.keywordSymptomatologyspa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordAnimalspa
dc.subject.keywordComplicationspa
dc.subject.keywordLimbic systemspa
dc.subject.keywordMemory disorderspa
dc.subject.keywordMental stressspa
dc.subject.keywordMetabolismspa
dc.subject.keywordPathologyspa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordAnimalsspa
dc.subject.keywordHumansspa
dc.subject.keywordLimbic systemspa
dc.subject.keywordMemory disordersspa
dc.subject.keywordOpioid peptidesspa
dc.subject.keywordStresseng
dc.subject.keywordMemoryspa
dc.subject.keywordNeuropsychiatric stress disordersspa
dc.subject.keywordOpioid systemspa
dc.subject.keywordStressspa
dc.titleThe opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's diseasespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
1-s2-0-S0278584618301799-main.pdf
Tamaño:
1.11 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos