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3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria

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dc.audienceComunidad Rosaristaspa
dc.creatorPatarroyo, Manuel A.
dc.creatorBermudez, Adriana
dc.creatorLópez, Carolina
dc.creatorYepes, Gloria
dc.creatorPatarroyo, Manuel E.
dc.creator.googlePatarroyo, Manuel A.
dc.creator.googleBermúdez, Adriana
dc.creator.googleLópez, Carolina
dc.creator.googleYepes, Gloria
dc.creator.googlePatarroyo, Manuel E.
dc.date.accessioned2014-08-12T16:06:42Z
dc.date.available2014-08-12T16:06:42Z
dc.date.created2010
dc.date.issued2010-03-19
dc.description.abstractT-cell receptor gene rearrangements were studied in Aotus monkeys developing high antibody titers and sterilizing immunity against the Plasmodium falciparum malaria parasite upon vaccination with the modified synthetic peptide 24112, which was identified in the Merozoite Surface Protein 2 (MSP-2) and is known to bind to HLA-DR beta 1*0403 molecules with high capacity. Spectratyping analysis showed a preferential usage of V beta 12 and V beta 6 TCR gene families in 67% of HLA-DR beta 1*0403-like genotyped monkeys. Docking of peptide 24112 into the HLA-DR beta 1*0401-HA peptide-HA1.7TCR complex containing the VDJ rearrangements identified in fully protected monkeys showed a different structural signature compared to nonprotected monkeys. These striking results show the exquisite specificity of the TCR/pMHCII complex formation needed for inducing sterilizing immunity and provide important hints for a logical and rational methodology to develop multiepitopic, minimal subunit-based synthetic vaccines against infectious diseases, among them malaria.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0009771
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8806
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 3
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 5
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 5 N. 3 Mar 19, 2010spa
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009771
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectReceptor de células Tspa
dc.subjectMhc Clase-iispa
dc.subjectMonos del nuevo mundospa
dc.subjectLas células rojas de la sangrespa
dc.subjectPlasmodium falciparumspa
dc.subjectEstructura cristalinaspa
dc.subjectHla-dr4 Dra-asterisco-0101spa
dc.subjectAotus-nancymaaespa
dc.subjectAminoácidosspa
dc.subjectDiversidadspa
dc.subject.ddcEnfermedades
dc.subject.decsMalariaspa
dc.subject.decsPlasmodiospa
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.decsInmunologíaspa
dc.subject.keywordT-cell-receptoreng
dc.subject.keywordMhc Class-iieng
dc.subject.keywordNew-world Monkeyseng
dc.subject.keywordRed-blood-cellseng
dc.subject.keywordPlasmodium-falciparumeng
dc.subject.keywordCrystal-structureeng
dc.subject.keywordHla-dr4 Dra-asterisk-0101eng
dc.subject.keywordAotus-nancymaaeeng
dc.subject.keywordAmino-acidseng
dc.subject.keywordDiversityeng
dc.title3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malariaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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