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Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

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dc.creatorSuárez M. C.F.spa
dc.creatorPatarroyo M.A.spa
dc.creatorPatarroyo M.E.spa
dc.date.accessioned2020-05-26T00:08:56Z
dc.date.available2020-05-26T00:08:56Z
dc.date.created2011spa
dc.description.abstractThe Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR. © 2010 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.gene.2010.09.006
dc.identifier.issn3781119
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24128
dc.language.isoengspa
dc.relation.citationEndPage45
dc.relation.citationIssueNo. 43862
dc.relation.citationStartPage37
dc.relation.citationTitleGene
dc.relation.citationVolumeVol. 470
dc.relation.ispartofGene, ISSN:3781119, Vol.470, No.43862 (2011); pp. 37-45spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78349310115&doi=10.1016%2fj.gene.2010.09.006&partnerID=40&md5=1f66c4fb4183f239f61b316aa26798f0spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMajor histocompatibility antigen class 2spa
dc.subject.keywordgeneticeng
dc.subject.keywordAotusspa
dc.subject.keywordArticlespa
dc.subject.keywordCatarrhinispa
dc.subject.keywordControlled studyspa
dc.subject.keywordExonspa
dc.subject.keywordFemalespa
dc.subject.keywordGenespa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordMalespa
dc.subject.keywordMhc dpa1 genespa
dc.subject.keywordMolecular cloningspa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordNatural selectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPlatyrrhinispa
dc.subject.keywordPriority journalspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordUnindexed sequencespa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAotidaespa
dc.subject.keywordExonsspa
dc.subject.keywordFemalespa
dc.subject.keywordHistocompatibility antigens class iispa
dc.subject.keywordHumansspa
dc.subject.keywordMajor histocompatibility complexspa
dc.subject.keywordMalespa
dc.subject.keywordModelseng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordSelectioneng
dc.subject.keywordAnimaliaspa
dc.subject.keywordAotus nancymaaespa
dc.subject.keywordAotus trivirgatusspa
dc.subject.keywordCatarrhinispa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPlatyrrhinispa
dc.subject.keywordPrimatesspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordMhc class ii moleculespa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordNew world monkeysspa
dc.subject.keywordPlatyrrhinispa
dc.titleCharacterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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