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Expert Consensus on the Use of Diphenhydramine for Short-Term Insomnia: Efficacy, Safety, and Clinical Applications

dc.creatorCalderón-Ospina, Carlos Albertospa
dc.creatorEcheverry, Jorgespa
dc.creatorAmado, Stevespa
dc.creatorParejo, Karemspa
dc.creatorAriza Salamanca, Daniel Felipe Venegas, Marcospa
dc.date.accessioned2025-07-21T16:42:16Z
dc.date.available2025-07-21T16:42:16Z
dc.date.created2025-05-09spa
dc.date.issued2025-05-09spa
dc.description.abstractInsomnia is the most prevalent sleep disorder, estimated to affect at least onethird of the global population. There are a variety of treatment options available for both acute and chronic insomnia. Currently, the pharmacological arsenal for treating insomnia includes short- or intermediate-acting benzodiazepine hypnotics, non-benzodiazepine hypnotic sedatives, melatonin receptor agonists, orexin receptor antagonist, and sedating antidepressants. Diphenhydramine, a first-generation antihistamine, is commonly used in the treatment of allergies and dermatitis. This review examines the preclinical and clinical efficacy and safety evidence of diphenhydramine in treating short-term insomnia. Additionally, it provides expert consensus on its implementation as an over-the-counter medication for this condition. The available evidence indicates that diphenhydramine is an effective treatment for acute insomnia in adults, offering a safe and affordable option for most patients suffering from this condition. Experts concur that there is strong evidence supporting the recommendation of diphenhydramine for the treatment of acute insomnia in adults.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.3390/jcm14103297spa
dc.identifier.issn2077-0383spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46063
dc.language.isoengspa
dc.publisherMDPIspa
dc.relation.ispartofJournal of Clinical Medicine 2025, 14, 3297spa
dc.relation.urihttps://www.mdpi.com/2077-0383/14/10/3297spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceJournal of Clinical Medicinespa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDiphenhydramineeng
dc.subject.keywordAntihistamineseng
dc.subject.keywordShort-term insomniaeng
dc.subject.keywordExperts’ consensuseng
dc.titleExpert Consensus on the Use of Diphenhydramine for Short-Term Insomnia: Efficacy, Safety, and Clinical Applicationsspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de revisiónspa
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