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Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis

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dc.creatorGómez L.M.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorSierra-Filardi E.spa
dc.creatorCadena J.spa
dc.creatorCorbí Á.spa
dc.creatorMartín J.spa
dc.date.accessioned2020-05-26T00:10:12Z
dc.date.available2020-05-26T00:10:12Z
dc.date.created2006spa
dc.description.abstractSeveral lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of DC-SIGN functional polymorphisms -336G/A SNP in the promoter region and insertion/deletion in the 'neck' region on the predisposition to tuberculosis. We performed an association study in 110 HIV-negative tuberculosis patients and 299 matched controls. In addition, a total of 155 healthy controls were screened for the tuberculin skin test (TST). DC-SIGN -336 SNP detection was performed by the real-time polymerase chain reaction technology, using the TaqMan 5? allele. The insertion/deletion in the 'neck' region was analyzed by polymerase chain reaction with specific primers. Although an increased frequency of the G allele in tuberculosis patients (23%), as compared with controls (19%), was observed, differences were not statistically significant (OR = 1.31, 95% CI = 0.89-1.94, P = 0.14). On the other hand, DC-SIGN repeat polymorphism in the 'neck' region had a very low frequency in the analyzed population. We conclude that the studied polymorphisms are not relevant risk factors for developing tuberculosis in Northwestern Colombian individuals. © 2006 American Society for Histocompatibility and Immunogenetics.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2006.07.003
dc.identifier.issn1988859
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24217
dc.language.isoengspa
dc.relation.citationEndPage811
dc.relation.citationIssueNo. 10
dc.relation.citationStartPage808
dc.relation.citationTitleHuman Immunology
dc.relation.citationVolumeVol. 67
dc.relation.ispartofHuman Immunology, ISSN:1988859, Vol.67, No.10 (2006); pp. 808-811spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33750003412&doi=10.1016%2fj.humimm.2006.07.003&partnerID=40&md5=8ca82a1ec403b3a8c3d316d466f793bcspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCD209 antigenspa
dc.subject.keywordAdultspa
dc.subject.keywordCell Surfaceeng
dc.subject.keywordSingle Nucleotideeng
dc.subject.keywordPulmonaryeng
dc.subject.keywordDelayedeng
dc.subject.keywordC-Typeeng
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDendritic cellspa
dc.subject.keywordFemalespa
dc.subject.keywordGene deletionspa
dc.subject.keywordGene insertionspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordNeckspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordPromoter regionspa
dc.subject.keywordReal time polymerase chain reactionspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordStatistical significancespa
dc.subject.keywordTuberculin testspa
dc.subject.keywordTuberculosisspa
dc.subject.keywordAdultspa
dc.subject.keywordCell Adhesion Moleculesspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenotypespa
dc.subject.keywordHeterozygotespa
dc.subject.keywordHomozygotespa
dc.subject.keywordHumansspa
dc.subject.keywordHypersensitivityeng
dc.subject.keywordLectinseng
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordReceptorseng
dc.subject.keywordTuberculosisspa
dc.subject.keywordTuberculosiseng
dc.subject.keywordCD209spa
dc.subject.keywordColombiaspa
dc.subject.keywordDC-SIGNspa
dc.subject.keywordTuberculin skin testspa
dc.subject.keywordTuberculosisspa
dc.titleAnalysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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