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Factors influencing polyautoimmunity in systemic lupus erythematosus

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dc.creatorRojas-Villarraga, Adriana
dc.creatorToro, Carlos-Enriquespa
dc.creatorEspinosa, Gerardspa
dc.creatorRodríguez-Velosa, Yolimaspa
dc.creatorDuarte-Rey, Carolina
dc.creatorMantilla, Rubén D.spa
dc.creatorIglesias-Gamarra, Antoniospa
dc.creatorCervera, Ricardspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:37Z
dc.date.available2020-05-26T00:01:37Z
dc.date.created2010spa
dc.description.abstractObjective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2009.10.001
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23389
dc.language.isoengspa
dc.relation.citationEndPage232
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage229
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 9
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.9, No.4 (2010); pp. 229-232spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-73849127374&doi=10.1016%2fj.autrev.2009.10.001&partnerID=40&md5=7309cbdf99523babdb0501b6104105a2spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordRibonucleoprotein antibodyspa
dc.subject.keywordautoimmuneeng
dc.subject.keywordsystemiceng
dc.subject.keywordRo antibodyspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordAutoimmune thyroiditisspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordClinical featurespa
dc.subject.keywordCluster analysisspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordHumanspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPhenotypespa
dc.subject.keywordReviewspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSex differencespa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordEthnic groupsspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMalespa
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordThyroiditiseng
dc.subject.keywordFamilial autoimmunityspa
dc.subject.keywordMultiple autoimmune syndromespa
dc.subject.keywordPolyautoimmunityspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleFactors influencing polyautoimmunity in systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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