Ítem
Acceso Abierto

Asociación entre trombosis venosa portal y mortalidad en pacientes en lista de espera de trasplante hepático

Mostrar el registro sencillo de la publicación
dc.contributor.advisorHernández Cely, Geovanny
dc.contributor.advisorSanabria Jiménez, Angélica María
dc.contributor.gruplacEducación Médica y en Ciencias de la Salud
dc.creatorCamargo Sánchez, Laura Patricia
dc.creatorBeltrán Galvis, Oscar Alfredo
dc.creatorMorales Cruz, Ximena del Pilar
dc.creator.degreeEspecialista en Gastroenterología
dc.creator.degreeLevelMaestría
dc.date.accessioned2026-02-09T19:24:28Z
dc.date.available2026-02-09T19:24:28Z
dc.date.created2026-01-26
dc.descriptionIntroducción: La cirrosis hepática es una enfermedad prevalente de curso clínico variable, caracterizada por múltiples complicaciones en su historia natural. Entre estas destaca la trombosis venosa portal (TVP), condición relacionada con diversos factores de riesgo y pronóstico adverso Objetivo: Determinar la relación entre TVP y mortalidad en los pacientes de lista de espera de trasplante hepático de la Fundación Cardioinfantil y describir características demográficas de la población como primera fase del estudio. Metodología: Estudio de cohortes retrospectivo que incluye los pacientes en lista de espera de trasplante hepático entre 2018 y 2024 de la Fundación Cardioinfantil. Se realizó análisis bivariado para el desenlace principal y de regresión logística para determinar los factores clínicos y paraclínicos asociados a TVP. Resultados: Se incluyeron 301 pacientes. La edad promedio fue de 58 años, el 58% eran mujeres y la etiología más frecuente de la cirrosis fue autoinmune. La prevalencia de TVP fue del 26% (n = 78) y no se observó un aumento significativo en la mortalidad en el grupo con TVP en comparación con el grupo sin esta condición (OR: 1.25; IC 95%: 0.55–2.87). Los factores asociados de manera independiente con la TVP fueron ascitis (OR = 2.03; IC 95%: 1.06–4.00; p = 0.036) y trombocitopenia en todos sus niveles: <50,000/µL (OR = 7.46; p = 0.001), 50,000–100,000/µL (OR = 4.20; p = 0.013) y 100,000–150,000/µL (OR = 6.25; p = 0.003). Conclusión: La presencia de TVP no se asoció con un aumento significativo de la mortalidad en pacientes en lista de espera para trasplante hepático en esta cohorte. La trombocitopenia y la ascitis se identificaron como variables relacionadas con la presencia de TVP.
dc.description.abstractIntroduction: Liver cirrhosis is a prevalent disease with a variable clinical course, characterized by multiple complications throughout its natural history. Among these, portal vein thrombosis (PVT) stands out as a condition linked to various risk factors and an adverse prognosis. Objective: To determine the relationship between PVT and mortality in liver transplant waitlist candidates at the Fundación Cardioinfantil and to describe the demographic characteristics of the population as the initial phase of the study. Methodology: A retrospective cohort study was conducted including patients on the liver transplant waitlist at the Fundación Cardioinfantil between 2018 and 2024. Bivariate analysis was performed for the primary outcome, and logistic regression was used to determine the clinical and paraclinical factors associated with PVT. Results: A total of 301 patients were included. The mean age was 58 years, 58% were female, and the most frequent etiology of cirrhosis was autoimmune. The prevalence of PVT was 26% (n = 78). No significant increase in mortality was observed in the PVT group compared to the non-PVT group (OR: 1.25; 95% CI: 0.55–2.87). Factors independently associated with PVT were ascites (OR = 2.03; 95% CI: 1.06–4.00; p = 0.036) and thrombocytopenia across all levels: <50,000/µL (OR = 7.46; p = 0.001), 50,000–100,000/µL (OR = 4.20; p = 0.013), and 100,000–150,000/µL (OR = 6.25; p = 0.003). Conclusion: The presence of PVT was not associated with a significant increase in mortality among liver transplant waitlist candidates in this cohort. Thrombocytopenia and ascites were identified as variables related to the presence of PVT.
dc.format.extent49 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_47491
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/47491
dc.language.isospa
dc.publisherUniversidad del Rosario
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Gastroenterología
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.source.bibliographicCitationHuang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, et al. Global epidemiology of cirrhosis — aetiology, trends and predictions. Nat Rev Gastroenterol Hepatol [Internet]. 2023;20(6):388–98. Disponible en: http://dx.doi.org/10.1038/s41575-023-00759-2
dc.source.bibliographicCitationLiu Y-B, Chen M-K. Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions. World J Gastroenterol [Internet]. 2022;28(41):5910–30. Disponible en: http://dx.doi.org/10.3748/wjg.v28.i41.5910 3. Zhai M, Long J, Liu S, Liu C, Li L, Yang L, et al. The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017. Aging (Albany NY) [Internet]. 2021;13(1):279–300. Disponible en: http://dx.doi.org/10.18632/aging.104127 4. Zamani M, Alizadeh-Tabari S, Ajmera V, Singh S, Murad MH, Loomba R. Global prevalence of advanced liver fibrosis and cirrhosis in the general population: A systematic review and meta-analysis. Clin Gastroenterol Hepatol [Internet]. 2024; Disponible en: http://dx.doi.org/10.1016/j.cgh.2024.08.020 5. Moon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol [Internet]. 2020;18(12):2650–66. Disponible en: http://dx.doi.org/10.1016/j.cgh.2019.07.060 6. Toth JF, Barman P. Portal vein thrombosis: Before, during, and after liver transplant. Clin Liver Dis (Hoboken) [Internet]. 2023;22(1):14–7. Disponible en: http://dx.doi.org/10.1097/cld.0000000000000067 7. Senzolo M, Garcia-Tsao G, García-Pagán JC. Current knowledge and management of portal vein thrombosis in cirrhosis. J Hepatol [Internet]. 2021;75(2):442–53. Disponible en: http://dx.doi.org/10.1016/j.jhep.2021.04.029 8. Pan J, Wang L, Gao F, An Y, Yin Y, Guo X, et al. Epidemiology of portal vein thrombosis in liver cirrhosis: A systematic review and meta-analysis. Eur J Intern Med [Internet]. 2022;104:21–32. Disponible en: http://dx.doi.org/10.1016/j.ejim.2022.05.032 9. Karvellas C, Cardoso F, Senzolo M, et al. Clinical Impact of Portal Vein Thrombosis Prior to Liver Transplantation: A Retrospective Cohort Study. Ann Hepatol [Internet]. 2017;16(2):236–46. Disponible en: http://dx.doi.org/10.5604/16652681.1231582 10. Cho JY, Suh K-S, Shin WY, Lee HW, Yi N-J, Lee KU. Thrombosis confined to the portal vein is not a contraindication for living donor liver transplantation. World J Surg [Internet]. 2008;32(8):1731–7. Disponible en: http://dx.doi.org/10.1007/s00268-008-9651-4 11. Koti RS, Tzerbinis H, Davidson BR. Liver Diseases [Internet]. Springer; 2020 [revision 2020, consultado 2024 Oct 14]. Disponible en: https://link.springer.com/book/10.1007/978-3-030-24432-3#bibliographic-information 12. Pinelli D, Cescon M, Ravaioli M, Neri F, Amaduzzi A, Serenari M, et al. Liver transplantation in patients with portal vein thrombosis: Revisiting outcomes according to surgical techniques. J Clin Med [Internet]. 2023;12(7):2457. Disponible en: http://dx.doi.org/10.3390/jcm12072457 13. O’Leary JG, Greenberg CS, Patton HM, Caldwell SH. AGA clinical practice update: Coagulation in cirrhosis. Gastroenterology [Internet]. 2019;157(1):34-43.e1. Disponible en: http://dx.doi.org/10.1053/j.gastro.2019.03.070 14. Boccatonda A, Gentilini S, Zanata E, Simion C, Serra C, Simioni P, et al. Portal vein thrombosis: State-of-the-art review. J Clin Med [Internet]. 2024;13(5):1517. Disponible en: http://dx.doi.org/10.3390/jcm13051517 15. Intagliata NM, Caldwell SH, Tripodi A. Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis. Gastroenterology [Internet]. 2019;156(6):1582-1599.e1. Disponible en: http://dx.doi.org/10.1053/j.gastro.2019.01.265 16. Stotts MJ, Wentworth BJ, Northup PG. Management of portal vein thrombosis in cirrhosis. Semin Liver Dis [Internet]. 2021;41(01):079–86. Disponible en: http://dx.doi.org/10.1055/s-0040-1722260 17. Hernández-Conde M, Llop E, de la Revilla Juan, et al. Prevalence and outcome of portal thrombosis in a cohort of cirrhotic patients undergoing liver transplantation. Rev Esp Enferm Dig [Internet]. 2016; 108(11); 716-720 18. Rivera J, Cárdenas B, Mantilla O, Bacilio W, Padilla-Machaca PM, Rondón C, et al. Trombosis venosa portal en pacientes sometidos a trasplante de hígado. Rev Gastroenterol Peru [Internet]. 2019;39(3):258-264. Disponible en: http://www.scielo.org.pe/pdf/rgp/v39n3/a09v39n3.pdf 19. Garcia-Tsao G, Abraldes JG, Rich NE, Wong VW-S. AGA clinical practice update on the use of vasoactive drugs and intravenous albumin in cirrhosis: Expert review. Gastroenterology [Internet]. 2024;166(1):202–10. Disponible en: http://dx.doi.org/10.1053/j.gastro.2023.10.016 20. Bosch J, Abraldes J, Berzigotti A, Garcia-Pagan J. Portal hypertension and gastrointestinal bleeding. Semin Liver Dis [Internet]. 2008;28(1):003–25. Disponible en: http://dx.doi.org/10.1055/s-2008-1040318 21. Simonetto DA, Singal AK, Garcia-Tsao G, Caldwell SH, Ahn J, Kamath PS. ACG clinical guideline: Disorders of the hepatic and mesenteric circulation. Am J Gastroenterol [Internet]. 2020;115(1):18–40. Disponible en: http://dx.doi.org/10.14309/ajg.0000000000000486 22. John BV, Konjeti R, Aggarwal A, Lopez R, Atreja A, Miller C, et al. Impact of untreated portal vein thrombosis on pre and post liver transplant outcomes in cirrhosis. Ann Hepatol [Internet]. 2013;12(6):952-958. Disponible en: https://pdf.sciencedirectassets.com/321204/1-s2.0-S1665268113X70395/1-s2.0-S1665268119313018/main.pdf?X 23. Amitrano L, Anna Guardascione M, Brancaccio V, Margaglione M, Manguso F, Iannaccone L, et al. Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. J Hepatol [Internet]. 2004;40(5):736–41. Disponible en: http://dx.doi.org/10.1016/j.jhep.2004.01.001 24. Nery F, Chevret S, Condat B, de Raucourt E, Boudaoud L, Rautou P-E, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study. Hepatology [Internet]. 2015;61(2):660–7. Disponible en: http://dx.doi.org/10.1002/hep.27546 25. DeLeve LD, Valla D-C, Garcia-Tsao G. Vascular disorders of the liver. Hepatology [Internet]. 2009;49(5):1729–64. Disponible en: http://dx.doi.org/10.1002/hep.22772 26. de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Abraldes JG, et al. Baveno VII – Renewing consensus in portal hypertension. J Hepatol [Internet]. 2022;76(4):959–74. Disponible en: http://dx.doi.org/10.1016/j.jhep.2021.12.022 27. Frances C, Mouquet C, Marcelin AG, Barete S, Agher R, Charron D, et al. Outcome of kidney transplant recipients with previous human Herpesvirus-8 infection1. Transplantation [Internet]. 2000;69(9):1776–9. Disponible en: http://dx.doi.org/10.1097/00007890-200005150-00008 28. Margini C, Berzigotti A. Portal vein thrombosis: The role of imaging in the clinical setting. Dig Liver Dis [Internet]. 2017;49(2):113–20. Disponible en: http://dx.doi.org/10.1016/j.dld.2016.11.013 29. Yang Y-H, Chen W-C, Tsan Y-T, Chen M-J, Shih W-T, Tsai Y-H, et al. Statin use and the risk of cirrhosis development in patients with hepatitis C virus infection. J Hepatol [Internet]. 2015;63(5):1111–7. Disponible en: http://dx.doi.org/10.1016/j.jhep.2015.07.006 30. Davis JPE, Lim JK, Francis FF, Ahn J. AGA clinical practice update on management of portal vein thrombosis in patients with cirrhosis: Expert review. Gastroenterology [Internet]. 2025;168(2):396-404.e1. Disponible en: http://dx.doi.org/10.1053/j.gastro.2024.10.038 31. Sarin SK, Philips CA, Kamath PS, Choudhury A, Maruyama H, Nery FG, et al. Toward a comprehensive new classification of portal vein thrombosis in patients with cirrhosis. Gastroenterology [Internet]. 2016;151(4):574-577.e3. Disponible en: http://dx.doi.org/10.1053/j.gastro.2016.08.033 32. Riley RD, Ensor J, Snell KIE, Harrell FE Jr, Martin GP, Reitsma JB, et al. Calculating the sample size required for developing a clinical prediction model. BMJ [Internet]. 2020;368:m441. Disponible en: http://dx.doi.org/10.1136/bmj.m441 33. Por la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud de 1993. No. 8430. [Internet]. Disponible en: https://www.minsalud.gov.co/sites/rid/lists/bibliotecadigital/ride/de/dij/resolucion-8430-de-1993.pdf 34. Koh JH, Liew ZH, Ng GK, Liu HT, Tam YC, De Gottardi A, et al. Efficacy and safety of direct oral anticoagulants versus vitamin K antagonist for portal vein thrombosis in cirrhosis: A systematic review and meta-analysis. Dig Liver Dis [Internet]. 2022;54(1):56–62. Disponible en: http://dx.doi.org/10.1016/j.dld.2021.07.039 35. Turon F, Shalaby S, García-Pagán JC, Hernández-Gea V. Management of portal vein thrombosis in liver transplant candidates. Liver Transpl [Internet]. 2024; Disponible en: http://dx.doi.org/10.1097/LVT.0000000000000531 36. Francoz C. Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation. Gut [Internet]. 2005;54(5):691–7. Disponible en: http://dx.doi.org/10.1136/gut.2004.042796 37. Delgado MG, Seijo S, Yepes I, Achécar L, Catalina MV, García-Criado Á, et al. Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis. Clin Gastroenterol Hepatol [Internet]. 2012;10(7):776–83. Disponible en: http://dx.doi.org/10.1016/j.cgh.2012.01.012 38. Berry K, Taylor J, Liou IW, Ioannou GN. Portal vein thrombosis is not associated with increased mortality among patients with cirrhosis. Clin Gastroenterol Hepatol [Internet]. 2015;13(3):585–93. Disponible en: http://dx.doi.org/10.1016/j.cgh.2014.10.010 39. Zanetto A, Rodriguez-Kastro K-I, Germani G, Ferrarese A, Cillo U, Burra P, et al. Mortality in liver transplant recipients with portal vein thrombosis - an updated meta-analysis. Transpl Int [Internet]. 2018;31(12):1318–29. Disponible en: http://dx.doi.org/10.1111/tri.13353 40. Guerrero A, Campo L del, Piscaglia F, Scheiner B, Han G, Violi F, et al. Anticoagulation improves survival in patients with cirrhosis and portal vein thrombosis: The IMPORTAL competing-risk meta-analysis. J Hepatol [Internet]. 2023;79(1):69–78. Disponible en: http://dx.doi.org/10.1016/j.jhep.2023.02.023 41. Tarar ZI, Farooq U, Kamal F, Nawaz A, Saleem S, Ghous G, et al. Safety of anticoagulation use for treatment of portal vein thrombosis in liver cirrhosis and its effect on hospital-based outcomes: an insight from a US nationwide database. Postgrad Med J [Internet]. 2023;99(1173):715–23. Disponible en: http://dx.doi.org/10.1136/pmj-2022-141915 42. Valeriani E, Di Nisio M, Riva N, Cohen O, Porreca E, Senzolo M, et al. Anticoagulant treatment for splanchnic vein thrombosis in liver cirrhosis: A systematic review and meta-analysis. Thromb Haemost [Internet]. 2021;121(07):867–76. Disponible en: http://dx.doi.org/10.1055/s-0040-1722192 43. Francoz C, Valla D, Durand F. Portal vein thrombosis, cirrhosis, and liver transplantation. J Hepatol [Internet]. 2012;57(1):203–12. Disponible en: http://dx.doi.org/10.1016/j.jhep.2011.12.034 44. Chang PE, Wong GW, Li JW, et al. Epidemiology and Clinical Evolution of Liver Cirrhosis in Singapore. Ann Acad Med Singap [Internet]. 2015;44(6):218-25. 45. Karlsen TH, Sheron N, Zelber-Sagi S, Carrieri P, Dusheiko G, Bugianesi E, et al. The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality. Lancet [Internet]. 2022;399(10319):61–116. Disponible en: http://dx.doi.org/10.1016/s0140-6736(21)01701-3 46. Rodríguez-Tajes S, Pocurull A, Castillo J, Casanova G, Vega L, Lens S, et al. Hepatitis C-related cirrhosis will be a marginal cause of hospital admissions by 2025. J Hepatol [Internet]. 2020;73(6):1360–7. Disponible en: http://dx.doi.org/10.1016/j.jhep.2020.07.018 47. Agbim U, Jiang Y, Kedia SK, Singal AK, Ahmed A, Bhamidimarri KR, et al. Impact of nonmalignant portal vein thrombosis in transplant recipients with nonalcoholic steatohepatitis: XXXX. Liver Transpl [Internet]. 2019;25(1):68–78. Disponible en: http://dx.doi.org/10.1002/lt.25322 48. Garcia-Compean D, Jaquez-Quintana JO, Gonzalez-Gonzalez JA, Maldonado-Garza H. Liver cirrhosis and diabetes: Risk factors, pathophysiology, clinical implications and management. World J Gastroenterol [Internet]. 2009;15(3):280. Disponible en: http://dx.doi.org/10.3748/wjg.15.280
dc.source.bibliographicCitationZhai M, Long J, Liu S, Liu C, Li L, Yang L, et al. The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017. Aging (Albany NY) [Internet]. 2021;13(1):279–300. Disponible en: http://dx.doi.org/10.18632/aging.104127
dc.source.bibliographicCitationZamani M, Alizadeh-Tabari S, Ajmera V, Singh S, Murad MH, Loomba R. Global prevalence of advanced liver fibrosis and cirrhosis in the general population: A systematic review and meta-analysis. Clin Gastroenterol Hepatol [Internet]. 2024; Disponible en: http://dx.doi.org/10.1016/j.cgh.2024.08.020
dc.source.bibliographicCitationMoon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol [Internet]. 2020;18(12):2650–66. Disponible en: http://dx.doi.org/10.1016/j.cgh.2019.07.060
dc.source.bibliographicCitationToth JF, Barman P. Portal vein thrombosis: Before, during, and after liver transplant. Clin Liver Dis (Hoboken) [Internet]. 2023;22(1):14–7. Disponible en: http://dx.doi.org/10.1097/cld.0000000000000067
dc.source.bibliographicCitationSenzolo M, Garcia-Tsao G, García-Pagán JC. Current knowledge and management of portal vein thrombosis in cirrhosis. J Hepatol [Internet]. 2021;75(2):442–53. Disponible en: http://dx.doi.org/10.1016/j.jhep.2021.04.029
dc.source.bibliographicCitationPan J, Wang L, Gao F, An Y, Yin Y, Guo X, et al. Epidemiology of portal vein thrombosis in liver cirrhosis: A systematic review and meta-analysis. Eur J Intern Med [Internet]. 2022;104:21–32. Disponible en: http://dx.doi.org/10.1016/j.ejim.2022.05.032
dc.source.bibliographicCitationKarvellas C, Cardoso F, Senzolo M, et al. Clinical Impact of Portal Vein Thrombosis Prior to Liver Transplantation: A Retrospective Cohort Study. Ann Hepatol [Internet]. 2017;16(2):236–46. Disponible en: http://dx.doi.org/10.5604/16652681.1231582
dc.source.bibliographicCitationCho JY, Suh K-S, Shin WY, Lee HW, Yi N-J, Lee KU. Thrombosis confined to the portal vein is not a contraindication for living donor liver transplantation. World J Surg [Internet]. 2008;32(8):1731–7. Disponible en: http://dx.doi.org/10.1007/s00268-008-9651-4
dc.source.bibliographicCitationKoti RS, Tzerbinis H, Davidson BR. Liver Diseases [Internet]. Springer; 2020 [revision 2020, consultado 2024 Oct 14]. Disponible en: https://link.springer.com/book/10.1007/978-3-030-24432-3#bibliographic-information
dc.source.bibliographicCitationPinelli D, Cescon M, Ravaioli M, Neri F, Amaduzzi A, Serenari M, et al. Liver transplantation in patients with portal vein thrombosis: Revisiting outcomes according to surgical techniques. J Clin Med [Internet]. 2023;12(7):2457. Disponible en: http://dx.doi.org/10.3390/jcm12072457
dc.source.bibliographicCitationO’Leary JG, Greenberg CS, Patton HM, Caldwell SH. AGA clinical practice update: Coagulation in cirrhosis. Gastroenterology [Internet]. 2019;157(1):34-43.e1. Disponible en: http://dx.doi.org/10.1053/j.gastro.2019.03.070
dc.source.bibliographicCitationBoccatonda A, Gentilini S, Zanata E, Simion C, Serra C, Simioni P, et al. Portal vein thrombosis: State-of-the-art review. J Clin Med [Internet]. 2024;13(5):1517. Disponible en: http://dx.doi.org/10.3390/jcm13051517
dc.source.bibliographicCitationIntagliata NM, Caldwell SH, Tripodi A. Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis. Gastroenterology [Internet]. 2019;156(6):1582-1599.e1. Disponible en: http://dx.doi.org/10.1053/j.gastro.2019.01.265
dc.source.bibliographicCitationStotts MJ, Wentworth BJ, Northup PG. Management of portal vein thrombosis in cirrhosis. Semin Liver Dis [Internet]. 2021;41(01):079–86. Disponible en: http://dx.doi.org/10.1055/s-0040-1722260
dc.source.bibliographicCitationHernández-Conde M, Llop E, de la Revilla Juan, et al. Prevalence and outcome of portal thrombosis in a cohort of cirrhotic patients undergoing liver transplantation. Rev Esp Enferm Dig [Internet]. 2016; 108(11); 716-720
dc.source.bibliographicCitationRivera J, Cárdenas B, Mantilla O, Bacilio W, Padilla-Machaca PM, Rondón C, et al. Trombosis venosa portal en pacientes sometidos a trasplante de hígado. Rev Gastroenterol Peru [Internet]. 2019;39(3):258-264. Disponible en: http://www.scielo.org.pe/pdf/rgp/v39n3/a09v39n3.pdf
dc.source.bibliographicCitationGarcia-Tsao G, Abraldes JG, Rich NE, Wong VW-S. AGA clinical practice update on the use of vasoactive drugs and intravenous albumin in cirrhosis: Expert review. Gastroenterology [Internet]. 2024;166(1):202–10. Disponible en: http://dx.doi.org/10.1053/j.gastro.2023.10.016
dc.source.bibliographicCitationBosch J, Abraldes J, Berzigotti A, Garcia-Pagan J. Portal hypertension and gastrointestinal bleeding. Semin Liver Dis [Internet]. 2008;28(1):003–25. Disponible en: http://dx.doi.org/10.1055/s-2008-1040318
dc.source.bibliographicCitationSimonetto DA, Singal AK, Garcia-Tsao G, Caldwell SH, Ahn J, Kamath PS. ACG clinical guideline: Disorders of the hepatic and mesenteric circulation. Am J Gastroenterol [Internet]. 2020;115(1):18–40. Disponible en: http://dx.doi.org/10.14309/ajg.0000000000000486
dc.source.bibliographicCitationJohn BV, Konjeti R, Aggarwal A, Lopez R, Atreja A, Miller C, et al. Impact of untreated portal vein thrombosis on pre and post liver transplant outcomes in cirrhosis. Ann Hepatol [Internet]. 2013;12(6):952-958. Disponible en: https://pdf.sciencedirectassets.com/321204/1-s2.0-S1665268113X70395/1-s2.0-S1665268119313018/main.pdf?X
dc.source.bibliographicCitationAmitrano L, Anna Guardascione M, Brancaccio V, Margaglione M, Manguso F, Iannaccone L, et al. Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. J Hepatol [Internet]. 2004;40(5):736–41. Disponible en: http://dx.doi.org/10.1016/j.jhep.2004.01.001
dc.source.bibliographicCitationNery F, Chevret S, Condat B, de Raucourt E, Boudaoud L, Rautou P-E, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study. Hepatology [Internet]. 2015;61(2):660–7. Disponible en: http://dx.doi.org/10.1002/hep.27546
dc.source.bibliographicCitationDeLeve LD, Valla D-C, Garcia-Tsao G. Vascular disorders of the liver. Hepatology [Internet]. 2009;49(5):1729–64. Disponible en: http://dx.doi.org/10.1002/hep.22772
dc.source.bibliographicCitationde Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Abraldes JG, et al. Baveno VII – Renewing consensus in portal hypertension. J Hepatol [Internet]. 2022;76(4):959–74. Disponible en: http://dx.doi.org/10.1016/j.jhep.2021.12.022
dc.source.bibliographicCitationFrances C, Mouquet C, Marcelin AG, Barete S, Agher R, Charron D, et al. Outcome of kidney transplant recipients with previous human Herpesvirus-8 infection1. Transplantation [Internet]. 2000;69(9):1776–9. Disponible en: http://dx.doi.org/10.1097/00007890-200005150-00008
dc.source.bibliographicCitationMargini C, Berzigotti A. Portal vein thrombosis: The role of imaging in the clinical setting. Dig Liver Dis [Internet]. 2017;49(2):113–20. Disponible en: http://dx.doi.org/10.1016/j.dld.2016.11.013
dc.source.bibliographicCitationYang Y-H, Chen W-C, Tsan Y-T, Chen M-J, Shih W-T, Tsai Y-H, et al. Statin use and the risk of cirrhosis development in patients with hepatitis C virus infection. J Hepatol [Internet]. 2015;63(5):1111–7. Disponible en: http://dx.doi.org/10.1016/j.jhep.2015.07.006
dc.source.bibliographicCitationDavis JPE, Lim JK, Francis FF, Ahn J. AGA clinical practice update on management of portal vein thrombosis in patients with cirrhosis: Expert review. Gastroenterology [Internet]. 2025;168(2):396-404.e1. Disponible en: http://dx.doi.org/10.1053/j.gastro.2024.10.038
dc.source.bibliographicCitationSarin SK, Philips CA, Kamath PS, Choudhury A, Maruyama H, Nery FG, et al. Toward a comprehensive new classification of portal vein thrombosis in patients with cirrhosis. Gastroenterology [Internet]. 2016;151(4):574-577.e3. Disponible en: http://dx.doi.org/10.1053/j.gastro.2016.08.033
dc.source.bibliographicCitationRiley RD, Ensor J, Snell KIE, Harrell FE Jr, Martin GP, Reitsma JB, et al. Calculating the sample size required for developing a clinical prediction model. BMJ [Internet]. 2020;368:m441. Disponible en: http://dx.doi.org/10.1136/bmj.m441
dc.source.bibliographicCitationPor la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud de 1993. No. 8430. [Internet]. Disponible en: https://www.minsalud.gov.co/sites/rid/lists/bibliotecadigital/ride/de/dij/resolucion-8430-de-1993.pdf
dc.source.bibliographicCitationKoh JH, Liew ZH, Ng GK, Liu HT, Tam YC, De Gottardi A, et al. Efficacy and safety of direct oral anticoagulants versus vitamin K antagonist for portal vein thrombosis in cirrhosis: A systematic review and meta-analysis. Dig Liver Dis [Internet]. 2022;54(1):56–62. Disponible en: http://dx.doi.org/10.1016/j.dld.2021.07.039
dc.source.bibliographicCitationTuron F, Shalaby S, García-Pagán JC, Hernández-Gea V. Management of portal vein thrombosis in liver transplant candidates. Liver Transpl [Internet]. 2024; Disponible en: http://dx.doi.org/10.1097/LVT.0000000000000531
dc.source.bibliographicCitationFrancoz C. Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation. Gut [Internet]. 2005;54(5):691–7. Disponible en: http://dx.doi.org/10.1136/gut.2004.042796
dc.source.bibliographicCitationDelgado MG, Seijo S, Yepes I, Achécar L, Catalina MV, García-Criado Á, et al. Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis. Clin Gastroenterol Hepatol [Internet]. 2012;10(7):776–83. Disponible en: http://dx.doi.org/10.1016/j.cgh.2012.01.012
dc.source.bibliographicCitationBerry K, Taylor J, Liou IW, Ioannou GN. Portal vein thrombosis is not associated with increased mortality among patients with cirrhosis. Clin Gastroenterol Hepatol [Internet]. 2015;13(3):585–93. Disponible en: http://dx.doi.org/10.1016/j.cgh.2014.10.010
dc.source.bibliographicCitationZanetto A, Rodriguez-Kastro K-I, Germani G, Ferrarese A, Cillo U, Burra P, et al. Mortality in liver transplant recipients with portal vein thrombosis - an updated meta-analysis. Transpl Int [Internet]. 2018;31(12):1318–29. Disponible en: http://dx.doi.org/10.1111/tri.13353
dc.source.bibliographicCitationGuerrero A, Campo L del, Piscaglia F, Scheiner B, Han G, Violi F, et al. Anticoagulation improves survival in patients with cirrhosis and portal vein thrombosis: The IMPORTAL competing-risk meta-analysis. J Hepatol [Internet]. 2023;79(1):69–78. Disponible en: http://dx.doi.org/10.1016/j.jhep.2023.02.023
dc.source.bibliographicCitationTarar ZI, Farooq U, Kamal F, Nawaz A, Saleem S, Ghous G, et al. Safety of anticoagulation use for treatment of portal vein thrombosis in liver cirrhosis and its effect on hospital-based outcomes: an insight from a US nationwide database. Postgrad Med J [Internet]. 2023;99(1173):715–23. Disponible en: http://dx.doi.org/10.1136/pmj-2022-141915
dc.source.bibliographicCitationValeriani E, Di Nisio M, Riva N, Cohen O, Porreca E, Senzolo M, et al. Anticoagulant treatment for splanchnic vein thrombosis in liver cirrhosis: A systematic review and meta-analysis. Thromb Haemost [Internet]. 2021;121(07):867–76. Disponible en: http://dx.doi.org/10.1055/s-0040-1722192
dc.source.bibliographicCitationFrancoz C, Valla D, Durand F. Portal vein thrombosis, cirrhosis, and liver transplantation. J Hepatol [Internet]. 2012;57(1):203–12. Disponible en: http://dx.doi.org/10.1016/j.jhep.2011.12.034
dc.source.bibliographicCitationChang PE, Wong GW, Li JW, et al. Epidemiology and Clinical Evolution of Liver Cirrhosis in Singapore. Ann Acad Med Singap [Internet]. 2015;44(6):218-25.
dc.source.bibliographicCitationKarlsen TH, Sheron N, Zelber-Sagi S, Carrieri P, Dusheiko G, Bugianesi E, et al. The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality. Lancet [Internet]. 2022;399(10319):61–116. Disponible en: http://dx.doi.org/10.1016/s0140-6736(21)01701-3
dc.source.bibliographicCitationRodríguez-Tajes S, Pocurull A, Castillo J, Casanova G, Vega L, Lens S, et al. Hepatitis C-related cirrhosis will be a marginal cause of hospital admissions by 2025. J Hepatol [Internet]. 2020;73(6):1360–7. Disponible en: http://dx.doi.org/10.1016/j.jhep.2020.07.018
dc.source.bibliographicCitationAgbim U, Jiang Y, Kedia SK, Singal AK, Ahmed A, Bhamidimarri KR, et al. Impact of nonmalignant portal vein thrombosis in transplant recipients with nonalcoholic steatohepatitis: XXXX. Liver Transpl [Internet]. 2019;25(1):68–78. Disponible en: http://dx.doi.org/10.1002/lt.25322
dc.source.bibliographicCitationGarcia-Compean D, Jaquez-Quintana JO, Gonzalez-Gonzalez JA, Maldonado-Garza H. Liver cirrhosis and diabetes: Risk factors, pathophysiology, clinical implications and management. World J Gastroenterol [Internet]. 2009;15(3):280. Disponible en: http://dx.doi.org/10.3748/wjg.15.280
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectTrombosis venosa portal
dc.subjectMortalidad
dc.subjectLista de trasplante hepático
dc.subjectTrombocitopenia
dc.subjectAscitis
dc.subject.keywordPortal vein thrombosis
dc.subject.keywordMortality
dc.subject.keywordLiver transplant waitlist
dc.subject.keywordThrombocytopenia
dc.subject.keywordAscites
dc.titleAsociación entre trombosis venosa portal y mortalidad en pacientes en lista de espera de trasplante hepático
dc.title.TranslatedTitleAssociation between portal vein thrombosis and mortality in patients on the liver transplant waitlist
dc.title.alternativeTrombosis portal y mortalidad en trasplante hepático
dc.typemasterThesis
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de grado
local.department.reportEscuela de Medicina y Ciencias de la Salud
local.regionesBogotá
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Asociacion_entre_trombosis_venosa_portal_y_mortalidad_en_pacientes.pdf
Tamaño:
544.28 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Especialización en Gastroenterología