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The diagnostic performance of classical molecular tests used for detecting human papillomavirus

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dc.creatorMunoz, Marinaspa
dc.creatorCamargo, Milenaspa
dc.creatorLeon, Sara C. Soto-Despa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorSanchez, Ricardospa
dc.creatorJaimes, Camilospa
dc.creatorPerez-Prados, Antoniospa
dc.creatorPatarroyo, Manuel E.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-25T23:56:43Z
dc.date.available2020-05-25T23:56:43Z
dc.date.created2012spa
dc.description.abstractCervical samples were evaluated for human papillomavirus (HPV) presence using the hybrid capture-2 (HC2) assay and the polymerase chain reaction (PCR) with three different primer sets (GP5+/6+, MY09/11 and pU1M/2R). PCR results were compared to HC2 and results of all assays were compared to cytological and colposcopy findings. Post-test probability was assessed in individual assays and test combinations. HPV-DNA prevalence was 36.5% with HC2 and 55.2% with PCR. MY09/11 detected HPV-DNA in 38% of samples, GP5+/6+ in 19.1% and pU1M/2R in 16.4%. pU1M/2R and HC2 had the highest concordance (75.31%, k= 0.39 in the whole population; 74.1%, k= 0.5 in women with abnormal cytology). pU1M/2R had the best diagnostic performance, including optimal post-test probabilities and cervical abnormality detection (individually or in a panel of tests). Women positive for pU1M/2R may be at higher risk of disease progression; the assay performance when combined with a Pap smear in cervical cancer screening programs should be evaluated. © 2012 Elsevier B.V..eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jviromet.2012.05.023
dc.identifier.issn1660934
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22494
dc.language.isoengspa
dc.relation.citationEndPage38
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage32
dc.relation.citationTitleJournal of Virological Methods
dc.relation.citationVolumeVol. 185
dc.relation.ispartofJournal of Virological Methods, ISSN:1660934, Vol.185, No.1 (2012); pp. 32-38spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84864324188&doi=10.1016%2fj.jviromet.2012.05.023&partnerID=40&md5=3165ee74600132b05b1a42afc665f3c4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordVirus DNAspa
dc.subject.keywordAbnormal laboratory resultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAnalytic methodspa
dc.subject.keywordArticlespa
dc.subject.keywordCancer screeningspa
dc.subject.keywordColposcopyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease coursespa
dc.subject.keywordFemalespa
dc.subject.keywordHigh risk populationspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordHybrid capture assay 2spa
dc.subject.keywordIntermethod comparisonspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPapanicolaou testspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPost test probabilityspa
dc.subject.keywordPriority journalspa
dc.subject.keywordStatistical parametersspa
dc.subject.keywordUterine cervix cancerspa
dc.subject.keywordUterine cervix cytologyspa
dc.subject.keywordVirus detectionspa
dc.subject.keywordVirus DNA cell DNA interactionspa
dc.subject.keywordWart virusspa
dc.subject.keywordAdultspa
dc.subject.keywordCervix Uterispa
dc.subject.keywordColposcopyspa
dc.subject.keywordCytological Techniquesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMolecular Diagnostic Techniquesspa
dc.subject.keywordNucleic Acid Hybridizationspa
dc.subject.keywordPapillomaviridaespa
dc.subject.keywordPapillomavirus Infectionsspa
dc.subject.keywordPolymerase Chain Reactionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordSensitivity and Specificityspa
dc.subject.keywordVirologyspa
dc.subject.keywordYoung Adultspa
dc.subject.keywordHuman papillomavirusspa
dc.subject.keywordHuman papillomavirusspa
dc.subject.keywordHybrid capture assay 2spa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordScreeningspa
dc.subject.keywordTest performancespa
dc.titleThe diagnostic performance of classical molecular tests used for detecting human papillomavirusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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