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Central nervous system compromise in primary Sjogren's syndrome.

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorRestrepo, Lucasspa
dc.creatorMolina, Jose Fspa
dc.creatorMantilla, Ruben Dspa
dc.creatorVargas, Sergiospa
dc.creatorVilla, Luis Aspa
dc.date.accessioned2020-08-19T14:41:50Z
dc.date.available2020-08-19T14:41:50Z
dc.date.created2002spa
dc.description.abstractCentral nervous system (CNS) involvement in primary Sjogren's syndrome (SS) is poorly understood, and its frequency as well as its manifestations are subjects of controversy. The current study was undertaken to determine the prevalence and the clinical and immunogenetic characteristics of CNS compromise in a well defined group of patients with primary SS. In this retrospective study, patients fulfilled the European classification criteria. Among 120 patients with primary SS, 3 (2.5%) had CNS compromise (multiple sclerosis-like illness, complicated migraine, and optic neuritis with epilepsy). The CNS involvement coincided with the onset of sicca symptoms in 1 case. All 3 patients carried the human leukocyte antigen (HLA) DQB1*0303 allele and tested positive for anti-Ro antibodies, but not for anti-cardiolipin antibodies. Although rare, CNS compromise in primary SS can be the presenting manifestation of the disease in a few cases, and may be severe and varied.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 1076-1608
dc.identifier.issnEISSN: 1536-7355
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27346
dc.language.isoengspa
dc.publisherCanadian Rheumatology Associationspa
dc.relation.citationEndPage196
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage189
dc.relation.citationTitleJournal of Clinical Rheumatology
dc.relation.citationVolumeVol. 8
dc.relation.ispartofJournal of Clinical Rheumatology, ISSN: 1076-1608; EISSN: 1536-7355, Vol.8, No.4 (2002); pp. 189-196spa
dc.relation.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=prem&NEWS=N&AN=17041358spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceJournal of Clinical Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSjögren’s syndromespa
dc.subject.keywordCentral nervous systemspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordMigrainespa
dc.subject.keywordHuman leukocyte antigenspa
dc.subject.keywordColombiaspa
dc.titleCentral nervous system compromise in primary Sjogren's syndrome.spa
dc.title.TranslatedTitleCompromiso del sistema nervioso central en el síndrome de Sjogren primario.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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