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Phospholipid supplementation can attenuate vaccine-induced depressive-like behavior in mice

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dc.creatorKivity S.spa
dc.creatorArango M.-T.spa
dc.creatorMolano González, Nicolásspa
dc.creatorBlank M.spa
dc.creatorShoenfeld Y.spa
dc.date.accessioned2020-05-26T00:11:07Z
dc.date.available2020-05-26T00:11:07Z
dc.date.created2017spa
dc.description.abstractHuman papillomavirus vaccine (HPVv) is used worldwide for prevention of infection. However several reports link this vaccine, with immune-mediated reactions, especially with neurological manifestations. Our previous results showed that HPVv-Gardasil and aluminum-immunized mice developed behavioral impairments. Studies have shown a positive effect of phospholipid supplementation on depression and cognitive functions in mice. Therefore, our goal was to evaluate the effect of a dietary supplement on vaccine-induced depression. Sixty C57BL/6 female mice were immunized with HPVv-Gardasil, aluminum or the vehicle (n = 20 each group), and half of each group were fed 5 times per week with 0.2 ml of a dietary supplement enriched with phosphatidylcholine. The mice were evaluated for depression at 3 months of age, by the forced swimming test. Both the Gardasil and the aluminum-treated mice developed depressive-like behavior when compared to the control group. The HPVv-Gardasil-immunized mice supplemented with phosphatidylcholine significantly reduced their depressive symptoms. This study confirms our previous studies demonstrating depressive-like behavior in mice vaccinated with HPVv-Gardasil. In addition, it demonstrates the ability of phosphatidylcholine-enriched diet to attenuate depressive-like behavior in the HPVv-Gardasil-vaccinated mice. We suggest that phosphatidylcholine supplementation may serve as a treatment for patients suffering vaccine-related neurological manifestations. © 2016, Springer Science+Business Media New York.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12026-016-8818-6
dc.identifier.issn0257277X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24282
dc.language.isoengspa
dc.publisherHumana Press Inc.spa
dc.relation.citationEndPage105
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage99
dc.relation.citationTitleImmunologic Research
dc.relation.citationVolumeVol. 65
dc.relation.ispartofImmunologic Research, ISSN:0257277X, Vol.65, No.1 (2017); pp. 99-105spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84980018603&doi=10.1007%2fs12026-016-8818-6&partnerID=40&md5=e12c6ba2e41eb0a2d99d8df9522ec66cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordPhospholipidspa
dc.subject.keywordimmunologiceng
dc.subject.keywordinbred c57bleng
dc.subject.keywordanimaleng
dc.subject.keywordpharmaceuticeng
dc.subject.keywordWart virus vaccinespa
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordImmunological adjuvantspa
dc.subject.keywordPharmaceutical vehicles and additivesspa
dc.subject.keywordPhospholipidspa
dc.subject.keywordWart virus vaccinespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordArticlespa
dc.subject.keywordBody weightspa
dc.subject.keywordConcentration (parameters)spa
dc.subject.keywordControlled studyspa
dc.subject.keywordDepressionspa
dc.subject.keywordDiet supplementationspa
dc.subject.keywordFemalespa
dc.subject.keywordForced swim testspa
dc.subject.keywordImmunizationspa
dc.subject.keywordMotor performancespa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPhospholipidspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRotarod testspa
dc.subject.keywordSingle drug dosespa
dc.subject.keywordAnimalspa
dc.subject.keywordAnimal behaviorspa
dc.subject.keywordC57bl mousespa
dc.subject.keywordDepressionspa
dc.subject.keywordDietary supplementspa
dc.subject.keywordDrug effectsspa
dc.subject.keywordMotor activityspa
dc.subject.keywordSwimmingspa
dc.subject.keywordVaccinationspa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAdjuvantseng
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordAnimalsspa
dc.subject.keywordBehavioreng
dc.subject.keywordDepressionspa
dc.subject.keywordDietary supplementsspa
dc.subject.keywordFemalespa
dc.subject.keywordHuman papillomavirus recombinant vaccine quadrivalent, types 6, 11, 16, 18spa
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordMotor activityspa
dc.subject.keywordPhospholipidsspa
dc.subject.keywordSwimmingspa
dc.subject.keywordVaccinationspa
dc.subject.keywordAluminumspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBehaviorspa
dc.subject.keywordDepressionspa
dc.subject.keywordGardasilspa
dc.titlePhospholipid supplementation can attenuate vaccine-induced depressive-like behavior in micespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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