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The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians

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dc.creatorFranco, Juan-Sebastian
dc.creatorMolano González, Nicolás
dc.creatorRodríguez Jiménez, Mónica María del Pilar
dc.creatorAcosta Ampudia, Yeny Yasbleidy
dc.creatorMantilla, Rubén D.
dc.creatorAmaya-Amaya, Jenny
dc.creatorRojas-Villarraga, Adriana
dc.creatorAnaya, Juan-Manuel
dc.creator.googleFranco, Juan-Sebastianspa
dc.creator.googleMolano-González, Nicolásspa
dc.creator.googleRodríguez-Jiménez, Monicaspa
dc.creator.googleAcosta-Ampudia, Yenyspa
dc.creator.googleMantilla, Rubén D.spa
dc.creator.googleAmaya-Amaya, Jennyspa
dc.creator.googleRojas-Villarraga, Adrianaspa
dc.creator.googleAnaya, Juan-Manuelspa
dc.date.accessioned2020-04-22T03:42:50Z
dc.date.available2020-04-22T03:42:50Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractObjectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0110242
dc.identifier.issn1932-6203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21732
dc.language.isoengspa
dc.relation.citationIssueNo. 10
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203 Vol. 9, No. 10 (2014)spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0110242&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectAnticuerpo fosfolípidospa
dc.subjectAdultospa
dc.subjectSíndrome antifosfolípidospa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordPhospholipid antibodyspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordAdultspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.lembEnfermedades del sistema inmunológicospa
dc.subject.lembSíndrome antifosfolípidospa
dc.subject.lembLupus eritematoso sistémicospa
dc.titleThe coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombiansspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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