Ítem
Acceso Abierto
The autoimmune tautology
Título de la revista
Autores
Anaya, Juan-Manuel
Archivos
Fecha
2010
Directores
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Resumen
Abstract
Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes. © 2010 BioMed Central Ltd.
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Keywords
Autoimmunity , Editorial , Genetic risk , Genetic susceptibility , Immunogenetics , Autoimmune disease
