Ítem
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Prevalence of classic and non-classic antiphospholipid antibodies in multiple sclerosis
Título de la revista
Autores
Shor D.B.-A.
Weiss G.A.
Barzilai O.
Ram M.
Anaya, Juan-Manuel
Shoenfeld Y.
Sherer Y.
Fecha
2015
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Editor
Israel Medical Association
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Resumen
Abstract
Background: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings. Objectives: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS. Methods: Using the BioPlex™ 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls. Results: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine- ?2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups. Conclusions: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain. © 2015, Israel Medical Association. All rights reserved.
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Keywords
Beta2 glycoprotein 1 , Cardiolipin antibody , antiphospholipid , Immunoglobulin g , Immunoglobulin m , Phosphatidylethanolamine , Phosphatidylserine , Phospholipid antibody , Prothrombin , Prothrombin complex , Immunoglobulin g , Immunoglobulin m , Phospholipid antibody , Adult , Antibody titer , Article , Controlled study , Disease duration , Female , Flow cytometry , Fluorescence analysis , Human , Immunoassay , Major clinical study , Male , Middle aged , Multiple sclerosis , Protein expression , Blood , Case control study , Cross-sectional study , Immunology , Multiple sclerosis , Prevalence , Adult , Antibodies , Case-control studies , Cross-sectional studies , Female , Humans , Immunoglobulin g , Immunoglobulin m , Male , Middle aged , Multiple sclerosis , Prevalence , Antiphospholipid syndrome (aps) , Autoantibodies , Autoimmunity , Beta 2-glycoprotein 1 (?2gpi) , Cardiolipin , Immunoglobulin (ig) , Multiple sclerosis (ms)
