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Influence of STAT4 polymorphism in primary Sjögren's syndrome

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Palomino-Morales R.J.
Diaz-Gallo L.-M.
Witte T.
Anaya, Juan-Manuel
Martín J.



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Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95% CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright © 2010. All rights reserved.
Palabras clave
STAT4 protein , Single Nucleotide , Allele , Article , Autoimmunity , Cohort analysis , Colombia , Controlled study , Disease predisposition , DNA polymorphism , Female , Gene frequency , Genetic susceptibility , Genotype , Germany , Human , Major clinical study , Male , Priority journal , Single nucleotide polymorphism , Sjoegren syndrome , Adult , Alleles , Autoimmunity , Female , Gene Frequency , Genetic Association Studies , Genetic Predisposition to Disease , Genotype , Humans , Male , Odds Ratio , Phenotype , Polymorphism , Sjogren's Syndrome , STAT4 Transcription Factor , Autoimmunity , Genetic studies , Sjögren's syndrome , STAT4