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Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

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Pacheco Nieva, Yovana
Barahona-Correa, Julián
Monsalve Carmona, Diana Marcela
Acosta Ampudia, Yeny Yasbleidy
Rojas Quintana, Manuel Eduardo
Rodríguez Velandia, Yhojan Alexis
Saavedra, Juliana
Rodríguez Jiménez, Mónica María del Pilar
Mantilla, Rubén D.
Ramírez Santana, Heily Carolina



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BioMed Central Ltd.

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Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s).
Palabras clave
Alpha interferon , Autoantibody , systemic , antinuclear , Biological marker , Cytokine , Cytokine antibody , Double stranded dna antibody , Granulocyte colony stimulating factor , Phospholipid antibody , Antinuclear antibody , Autoantibody , Cytokine , Adult , Article , Controlled study , Cross-sectional study , Disease activity , Female , Human , Major clinical study , Personalized medicine , Systemic lupus erythematosus , Blood , Cluster analysis , Immunology , Middle aged , Systemic lupus erythematosus , Young adult , Adult , Antibodies , Autoantibodies , Cluster analysis , Cross-sectional studies , Cytokines , Female , Humans , Lupus erythematosus , Middle aged , Young adult , Anti-dsdna antibodies , Antiphospholipid antibodies , Autoantibodies , Cluster analysis , Cytokines , Interferon alpha , Interleukin 12p40 , Interleukin 8 , Personalized medicine , Subphenotypes , Systemic lupus erythematosus , Taxonomy
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