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Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Título de la revista
Pacheco Nieva, Yovana
Barahona-Correa, Julián
Monsalve, Diana M.
Acosta Ampudia, Yeny Yasbleidy
Rojas, Manuel
Rodríguez, Yhojan
Saavedra, Juliana
Rodríguez-Jímenez, Mónica
Mantilla, Rubén D.
Ramirez-Santana, Carolina



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Título del volumen
BioMed Central Ltd.


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Background: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed. Methods: This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile, and a panel of 15 serum cytokines were measured simultaneously. Mixed-cluster methodology and bivariate analyses were used to define autoantibody and cytokine clusters and to identify associations between them and related variables. Results: First, three clusters of autoantibodies were defined: (1) neutral, (2) antiphospholipid antibodies (APLA)-dominant, and (3) anti-dsDNA/ENA-dominant. Second, eight cytokines showed levels above the threshold thus making possible to find 4 clusters: (1) neutral, (2) chemotactic, (3) G-CSF dominant, and (4) IFN?/Pro-inflammatory. Furthermore, the disease activity was associated with cytokine clusters, which, in turn, were associated with autoantibody clusters. Finally, when all biomarkers were included, three clusters were found: (1) neutral, (2) chemotactic/APLA, and (3) IFN/dsDNA, which were also associated with disease activity. Conclusion: These results support the existence of three SLE cytokine-autoantibody driven subphenotypes. They encourage the practice of personalized medicine, and support proof-of-concept studies. © 2017 The Author(s).
Palabras clave
Alpha interferon , Autoantibody , systemic , antinuclear , Biological marker , Cytokine , Cytokine antibody , Double stranded dna antibody , Granulocyte colony stimulating factor , Phospholipid antibody , Antinuclear antibody , Autoantibody , Cytokine , Adult , Article , Controlled study , Cross-sectional study , Disease activity , Female , Human , Major clinical study , Personalized medicine , Systemic lupus erythematosus , Blood , Cluster analysis , Immunology , Middle aged , Systemic lupus erythematosus , Young adult , Adult , Antibodies , Autoantibodies , Cluster analysis , Cross-sectional studies , Cytokines , Female , Humans , Lupus erythematosus , Middle aged , Young adult , Anti-dsdna antibodies , Antiphospholipid antibodies , Autoantibodies , Cluster analysis , Cytokines , Interferon alpha , Interleukin 12p40 , Interleukin 8 , Personalized medicine , Subphenotypes , Systemic lupus erythematosus , Taxonomy