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Pharmacological venous thromboembolism prophylaxis in radical prostatectomy

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Valverde-Martinez, Sebastian
Gonzalez-Rayo, Laura-Andrea
Padilla-Fernandez, Barbara
Pereira-Bruno, Jorge
Coelho, Hugo
Montesino-Semper, Manuel
Müller-Arteaga, Carlos
Alvarez-Ossorio-Fernandez, Jose-Luis
Migliorini, Filippo
Garcia-Cenador, Maria-Begoña



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Ediciones Doyma, S.L.


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Background and aim: Pulmonary thromboembolism is one of the most common causes of non-surgical death in patients following urological abdominopelvic surgery. Since the beginning of prophylaxis for venous thromboembolic disease, episodes of deep vein thrombosis and pulmonary thromboembolism have decreased. Our objective is to analyse the prognosis factors of thromboembolic disease, the clinical variability in the use of pharmacological prophylaxis and the results of its application. Material and methods: Retrospective multicentric study of 610 patients undergoing radical prostatectomy between December 2013 and November 2014, in 7 general hospitals in Spain, Italy and Portugal. Patients were classified according to their baseline characteristics into thrombotic risk groups and haemorrhagic risk groups. The venous thromboembolic events that occurred in the different groups were analysed. Results: The average age was 65.22 years (48-78). The average body mass index was 26.7 and the average ASA risk 2.1. In all patients, early mobilization began in the first 24 hours. In 4.1% intermittent pneumatic compression was used and 84.6% received pharmacological prophylaxis with low molecular weight heparins. Only 3.4% used the combination of mechanical prophylaxis with pharmacological prophylaxis. We observed a decrease in the incidence of thromboembolic events in the patients who received pharmacological prophylaxis, with an absolute risk reduction of 6.8%. There was no increase in the risk of haemorrhage in the patients who received pharmacological prophylaxis. Conclusions: In this study on patients undergoing radical prostatectomy, there was no difference in haemorrhagic complications derived from the use of pharmacological prophylaxis for venous thromboembolic disease. Pharmacological prophylaxis reduces the risk of presenting a thromboembolic event in patients undergoing radical prostatectomy, although this risk is not associated with the approach technique. © 2019 Elsevier España, S.L.U.
Palabras clave
Anticoagulant agent , Low molecular weight heparin , Adult , Aged , Article , Bleeding , Body mass , Controlled study , Deep vein thrombosis , Device therapy , Disease risk assessment , Human , Incidence , Lung embolism , Major clinical study , Mobilization , Postoperative complication , Postoperative hemorrhage , Prognosis , Prostatectomy , Retrospective study , Risk reduction , Surgical risk , Thrombosis prevention , Venous thromboembolism , Clinical variability , Radical prostatectomy , Thromboembolic prophylaxis