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Divergent short- and long-term effects of acute stress in object recognition memory are mediated by endogenous opioid system activation

Título de la revista
Nava Mesa, Mauricio Orlando
Lamprea, Marisol R.
Múnera, Alejandro



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Título del volumen
Academic Press Inc.


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Acute stress induces short-term object recognition memory impairment and elicits endogenous opioid system activation. The aim of this study was thus to evaluate whether opiate system activation mediates the acute stress-induced object recognition memory changes. Adult male Wistar rats were trained in an object recognition task designed to test both short- and long-term memory. Subjects were randomly assigned to receive an intraperitoneal injection of saline, 1. mg/kg naltrexone or 3. mg/kg naltrexone, four and a half hours before the sample trial. Five minutes after the injection, half the subjects were submitted to movement restraint during four hours while the other half remained in their home cages. Non-stressed subjects receiving saline (control) performed adequately during the short-term memory test, while stressed subjects receiving saline displayed impaired performance. Naltrexone prevented such deleterious effect, in spite of the fact that it had no intrinsic effect on short-term object recognition memory. Stressed subjects receiving saline and non-stressed subjects receiving naltrexone performed adequately during the long-term memory test; however, control subjects as well as stressed subjects receiving a high dose of naltrexone performed poorly. Control subjects' dissociated performance during both memory tests suggests that the short-term memory test induced a retroactive interference effect mediated through light opioid system activation; such effect was prevented either by low dose naltrexone administration or by strongly activating the opioid system through acute stress. Both short-term memory retrieval impairment and long-term memory improvement observed in stressed subjects may have been mediated through strong opioid system activation, since they were prevented by high dose naltrexone administration. Therefore, the activation of the opioid system plays a dual modulating role in object recognition memory. © 2013 Elsevier Inc.
Palabras clave
Dynorphin , physical , Kappa opiate receptor , long-term , physiological , psychological , short-term , wistar , Naltrexone , Opiate , Acute stress , Animal experiment , Article , Controlled study , Environmental factor , Habitat , Human , Hypothalamus hypophysis system , Long term memory , Male , Memory , Memory disorder , Nonhuman , Opiod system , Pattern recognition , Physical activity , Rat , Recognition , Short term memory , Task performance , 1mg/kg naltrexone , 1mg/kg naltrexone plus no-stress , 1mg/kg naltrexone plus stress , 3mg/kg naltrexone , 3mg/kg naltrexone plus no-stress , 3mg/kg naltrexone plus stress , Acth , Acute stress , Adrenocorticotropic hormone , Analysis of variance , Anova , Di , Discrimination index , Endogenous opioid system , Familiar object , Fo , N1ns , N1s , N3ns , N3s , Nal 1 , Nal 3 , Naltrexone , No , Novel object , Object recognition memory , Object recognition memory , Object recognition task , Orm , Ort , Retroactive interference , Retroactive interference , Ri , Saline plus no-stress , Saline plus stress , Sem , Sns , Ss , Standard error of the mean , Tfo , Time spent exploring the familiar object , Time spent exploring the novel object , Tno , Veh , Vehicle , Animals , Male , Memory , Memory , Naltrexone , Narcotic antagonists , Opioid peptides , Rats , Rats , Recognition (psychology) , Restraint , Stress , Stress , Acute stress , Endogenous opioid system , Naltrexone , Object recognition memory , Retroactive interference