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Screening for mutations of the FOXO4 gene in premature ovarian failure patients
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Fonseca Mendoza, Dora Janeth
Garzón, Eliana
Lakhal, Besma
Braham, Rim
Ojeda, Diego
Elghezal, Hatem
Saâd, Ali
Restrepo Fernández, Carlos Martín
Laissue, Paul
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2012
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Abstract
FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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Foxo4 protein , dna , Unclassified drug , Article , Controlled study , Dna flanking region , Exon , Female , Female infertility , Gene expression , Gene mutation , Genetic screening , Genetic variability , Human , Major clinical study , Nucleotide sequence , Open reading frame , Pathogenesis , Polymerase chain reaction , Premature ovarian failure , Promoter region , Sequence analysis , Tunisia , Adult , Dna mutational analysis , Female , Gene frequency , Humans , Mutation , Open reading frames , Primary ovarian insufficiency , Promoter regions , Sequence analysis , Transcription factors , Tunisia , Female infertility , Foxo4 , Premature ovarian failure
