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NHP-immunome: A translational research-oriented database of non-human primate immune system proteins
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Autores
Plaza, David F.
Gómez, Manuel F.
Patarroyo, Manuel A.
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Fecha
2020
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Academic Press Inc.
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Abstract
We are currently living the advent of a new age for medicine in which basic research is being quickly translated into marketable drugs, and the widespread access to genomics data is allowing the design and implementation of personalized solutions to medical conditions. Non-human primates (NHP) have gained an essential role in drug discovery and safety testing due to their close phylogenetic relationship to humans. In this study, a collection of well characterized genes of the human immune system was used to define the orthology-based immunome in four NHP species, with carefully curated annotations available based on multi-tissue RNA-seq datasets. A broad variation in the frequency of expressed protein isoforms was observed between species. Finally, this analysis also revealed the lack of expression of at least four different chemokines in new-world primates. In addition, transcripts corresponding to four genes including interleukin 12 subunit alpha were expressed in humans but no other primate species analyzed. Access to the non-human primate immunome is available in http://www.fidic.org.co:90/proyecto/. © 2019 Elsevier Inc.
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Keywords
Interleukin 12p35 , Isoprotein , Aotus nancymaae , Article , Callithrix jacchus , Drug safety , Gene expression , Genetic transcription , Human , Immune system , Molecular phylogeny , Nonhuman , Pan troglodytes , Phylogeny , Primate , Priority journal , Protein expression , Rhesus monkey , Rna analysis , Rna sequence , Translational research , Aotus nancymaae , Callithrix jacchus , Immune system orthology , Macaca mulatta , Pan troglodytes , Splicing/protein isoforms
