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Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6

Título de la revista
Rojas M.
Rodríguez Velandia, Yhojan Alexis
Monsalve Carmona, Diana Marcela
Pacheco Y.
Acosta Ampudia, Yeny Yasbleidy
Rodríguez Jiménez, Mónica María del Pilar
Molano González, Nicolás
Mantilla R.D.
Ramírez Santana, Heily Carolina
Anaya, Juan-Manuel



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Título del volumen
NLM (Medline)


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OBJECTIVES: Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc. METHODS: Thirty-five consecutive women with established SSc were involved in this exploratory study. Clinical characteristics, including severity of symptoms and resilience, a panel of 15 serum cytokines and 17 autoantibodies were assessed simultaneously. Multivariate methods were used to analyse the data. RESULTS: Interleukin-6 (IL-6) levels were associated with severity of symptoms (?=1.8395, p=0.04), and low resilience scores (?= -0.581120, p=0.02). Furthermore, resilience was not associated with clinical manifestations nor polyautoimmunity. Cytokine levels did not significantly differ between groups based on regular physical activity. CONCLUSIONS: The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc.
Palabras clave
Autoantibody , systemic , Cytokine , Interleukin 6 , Blood , Female , Human , Immunology , Physiology , Severity of illness index , Systemic sclerosis , Autoantibodies , Cytokines , Female , Humans , Interleukin-6 , Scleroderma , Severity of illness index