Identidad Institucional CRAI
Logo EdocUR
    • English
    • español
    • português
  •  Work Submission
  •  FAQs
  • English 
    • English
    • español
    • português
  • Login

Contacto

Twitter

Facebook

Youtube

View Item 
  •   Repositorio Institucional EdocUR - Universidad del Rosario
  • Investigación
  • Artículos
  • View Item
  •   Repositorio Institucional EdocUR - Universidad del Rosario
  • Investigación
  • Artículos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Helicobacter pylori serology in autoimmune diseases - Fact or fiction?

  • Exportar citas ▼
    • Exportar a Mendeley
    • Exportar a BibTex
Thumbnail
Date
2013
Author
Ram, Maya
Barzilai, Ori
Shapira, Yinon
Anaya, Juan-ManuelAutoridad Universidad de Rosario
Tincani, Angela
Stojanovich, Ljudmila
Bombardieri, Stefano
Bizzaro, Nicola
Kivity, Shaye
Levin, Nancy Agmon
Shoenfeld, Yehuda
Métricas

Share
Citation
URI
https://doi.org/10.1515/cclm-2012-0477
https://repository.urosario.edu.co/handle/10336/23678

Abstract
"Background: The pathogenesis of autoimmunity is presumed to be a complex process including genetic predisposition, hormonal balance and environmental factors such as infectious agents . Helicobacter pylori , a common bacterial infectious agent has been associated with a variety of autoimmune disorders. However, this bacteria is also thought to play a protective role in the development of multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD). We tested various links between anti- H. pylori (anti-HP) antibodies and a wide profile of autoimmune diseases and autoantibodies. Methods: A total of 1290 patients diagnosed with 14 different autoimmune diseases from two geographical areas (Europe and Latin America) and two groups of healthy matching controls (n = 385) were screened for the presence of H. pylori IgG antibodies by "" pylori detect "" kit. In parallel, a large profile belonging to three groups of autoantibodies was tested in all sera (anti-nuclear antibodies, autoantibodies associated with thrombophilia and gastrointestinal diseases). Results: Our data demonstrate associations between anti-HP antibodies and anti-phospholipid syndrome, giant cell arteritis, systemic sclerosis and primary biliary cirrhosis. Our data also support a previously known negative association between the prevalence of anti-HP antibodies and IBD. Additionally, links were made between seropositivity to H. pylori and the presence of anti-nuclear antibodies, dsDNA, anti-Ro and some thrombophiliaassociated antibodies, as well as negative associations with gastrointestinal-associated antibodies. Conclusions: Whether these links are epiphenomenal or H. pylori does play a causative role in the autoimmune diseases remains uncertain. The negative associations could possibly support the notion that in susceptible individuals infections may protect from the development of autoimmune diseases."

Keyword

Antinuclear antibody ; Autoantibody ; Double stranded dna ; Immunoglobulin g antibody ; Antiphospholipid syndrome ; Article ; Autoimmune disease ; Controlled study ; Gastrointestinal disease ; Giant cell arteritis ; Helicobacter pylori ; Human ; Infection ; Major clinical study ; Primary biliary cirrhosis ; Priority journal ; Serology ; Systemic sclerosis ; Thrombophilia ; Antibodies, bacterial ; Antigen-antibody reactions ; Autoimmune diseases ; Blood chemical analysis ; Helicobacter infections ; Helicobacter pylori ; Humans ; Antibodies ; Autoantibodies ; Autoimmune diseases ; Autoimmunity ; Helicobacter pylori ; Infection ;

Source link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84882282125&doi=10.1515%2fcc...

Show full item record

Collections
  • Artículos [6079]
Política de Acceso Abierto URPortal de Revistas URRepositorio de Datos de Investigación URCiencia Abierta UR
 

 

Browse

All of DSpaceCommunities & CollectionsTitlesAuthorsTypeSubjectsAdvisorBy Issue DateThis CollectionTitlesAuthorsTypeSubjectsAdvisorBy Issue Date

My Account

LoginRegister

Statistics

View Usage Statistics
Política de Acceso Abierto URPortal de Revistas URRepositorio de Datos de Investigación URCiencia Abierta UR