Ítem
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Myalgic encephalomyelitis/chronic fatigue syndrome: A comprehensive review
Título de la revista
Autores
Cortes Rivera, Mateo
Mastronardi, Claudio
Silva-Aldana, Claudia T
Arcos-Burgos, Mauricio
Lidbury, Brett A
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Fecha
2019
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MDPI AG
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Resumen
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology that is recognized by the World Health Organization (WHO) and the United States Center for Disease Control and Prevention (US CDC) as a disorder of the brain. The disease predominantly affects adults, with a peak age of onset of between 20 and 45 years with a female to male ratio of 3:1. Although the clinical features of the disease have been well established within diagnostic criteria, the diagnosis of ME/CFS is still of exclusion, meaning that other medical conditions must be ruled out. The pathophysiological mechanisms are unclear but the neuro-immuno-endocrinological pattern of CFS patients gleaned from various studies indicates that these three pillars may be the key point to understand the complexity of the disease. At the moment, there are no specific pharmacological therapies to treat the disease, but several studies’ aims and therapeutic approaches have been described in order to benefit patients’ prognosis, symptomatology relief, and the recovery of pre-existing function. This review presents a pathophysiological approach to understanding the essential concepts of ME/CFS, with an emphasis on the population, clinical, and genetic concepts associated with ME/CFS. © 2019 by the authors.
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Keywords
2',5' oligoadenylate synthetase , Hydrocortisone , Immunoglobulin , Neurotransmitter , Ribonuclease l , Serotonin , Autoimmunity , B lymphocyte subpopulation , Cell activation , Central nervous system disease , Chronic fatigue syndrome , Clinical feature , Dna modification , Epigenetics , Genetic predisposition , Glia cell , Human , Hydrocortisone blood level , Hypothalamus hypophysis adrenal system , Immune dysregulation , Immune system , Immunoglobulin blood level , Inflammation , Natural killer cell , Nervous system inflammation , Neuroendocrinology , Neuroimmunology , Oxidative stress , Pathophysiology , Prognosis , Review , Sensitization , Serotoninergic transmission , Biomarker , Chronic fatigue syndrome , Epstein barr virus , Hypothalamic–pituitary–adrenal axis , Immunological , Myalgic encephalomyelitis , Neuroimmune
