Ítem
Solo Metadatos
Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine
Título de la revista
Autores
Patarroyo, Manuel E
Bermudez, Adriana
Moreno-Vranich, Armando
Resumen
Abstract
If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by 1H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria. © 2012 Expert Reviews Ltd.
Palabras clave
Keywords
Apical merozoite antigen 1 , subunit , Erythrocyte membrane protein 1 , Major histocompatibility antigen class 2 , Malaria vaccine , Merozoite surface protein , Parasite antigen , Rhoptry associated protein , Serine repeat antigen 5 , Sporozoite protein , T lymphocyte receptor , Unclassified drug , Drug efficacy , Drug synthesis , Drug targeting , Human , Immunogenicity , Malaria falciparum , Merozoite , Nonhuman , Pathogenesis , Plasmodium falciparum , Plasmodium knowlesi , Plasmodium vivax , Priority journal , Protein binding , Review , Sporozoite , Drug discovery , Humans , Magnetic resonance spectroscopy , Malaria vaccines , Malaria , Plasmodium falciparum , Protein conformation , Vaccines , Fully protective , Subunit-based , Synthetic antimalaria vaccine
