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Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)
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Suárez M. C.F.
Patarroyo M.A.
Patarroyo M.E.
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2011
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Abstract
The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR. © 2010 Elsevier B.V.
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Keywords
Major histocompatibility antigen class 2 , genetic , Aotus , Article , Catarrhini , Controlled study , Exon , Female , Gene , Genetic polymorphism , Male , Mhc dpa1 gene , Molecular cloning , Molecular evolution , Natural selection , Nonhuman , Nucleotide sequence , Phylogeny , Platyrrhini , Priority journal , Sequence analysis , Unindexed sequence , Amino acid sequence , Animals , Aotidae , Exons , Female , Histocompatibility antigens class ii , Humans , Major histocompatibility complex , Male , Models , Molecular sequence data , Selection , Animalia , Aotus nancymaae , Aotus trivirgatus , Catarrhini , Plasmodium falciparum , Plasmodium vivax , Platyrrhini , Primates , Animal model , Mhc class ii molecule , Molecular evolution , New world monkeys , Platyrrhini
