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STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians
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Palomino-Morales, R J
Rojas-Villarraga, A
González, C I
Ramírez, G
Anaya, Juan-Manuel
Martín, J
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2008
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Abstract
The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.
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Complement component C5 , Rheumatoid , STAT4 protein , Single Nucleotide , Systemic , Tumor necrosis factor receptor associated factor 1 , Article , Autoimmunity , Case control study , Colombia , Controlled study , Genetic polymorphism , Genetic risk , Genetic susceptibility , Genotype , Human , Major clinical study , Mouse strain , Polymerase chain reaction , Priority journal , Protein variant , Rheumatoid arthritis , Risk factor , Systemic lupus erythematosus , Alleles , Arthritis , Case-Control Studies , Cohort Studies , Colombia , Gene Frequency , Genotype , Humans , Lupus Erythematosus , Polymorphism , Risk Factors , STAT4 Transcription Factor , TNF Receptor-Associated Factor 1 , Variation (Genetics)
