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Phospholipid supplementation can attenuate vaccine-induced depressive-like behavior in mice

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Kivity S.
Arango M.-T.
Molano González, Nicolás
Blank M.
Shoenfeld Y.



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Humana Press Inc.

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Human papillomavirus vaccine (HPVv) is used worldwide for prevention of infection. However several reports link this vaccine, with immune-mediated reactions, especially with neurological manifestations. Our previous results showed that HPVv-Gardasil and aluminum-immunized mice developed behavioral impairments. Studies have shown a positive effect of phospholipid supplementation on depression and cognitive functions in mice. Therefore, our goal was to evaluate the effect of a dietary supplement on vaccine-induced depression. Sixty C57BL/6 female mice were immunized with HPVv-Gardasil, aluminum or the vehicle (n = 20 each group), and half of each group were fed 5 times per week with 0.2 ml of a dietary supplement enriched with phosphatidylcholine. The mice were evaluated for depression at 3 months of age, by the forced swimming test. Both the Gardasil and the aluminum-treated mice developed depressive-like behavior when compared to the control group. The HPVv-Gardasil-immunized mice supplemented with phosphatidylcholine significantly reduced their depressive symptoms. This study confirms our previous studies demonstrating depressive-like behavior in mice vaccinated with HPVv-Gardasil. In addition, it demonstrates the ability of phosphatidylcholine-enriched diet to attenuate depressive-like behavior in the HPVv-Gardasil-vaccinated mice. We suggest that phosphatidylcholine supplementation may serve as a treatment for patients suffering vaccine-related neurological manifestations. © 2016, Springer Science+Business Media New York.
Palabras clave
Aluminum hydroxide , Phospholipid , immunologic , inbred c57bl , animal , pharmaceutic , Wart virus vaccine , Aluminum hydroxide , Immunological adjuvant , Pharmaceutical vehicles and additives , Phospholipid , Wart virus vaccine , Animal experiment , Article , Body weight , Concentration (parameters) , Controlled study , Depression , Diet supplementation , Female , Forced swim test , Immunization , Motor performance , Mouse , Nonhuman , Phospholipid , Priority journal , Rotarod test , Single drug dose , Animal , Animal behavior , C57bl mouse , Depression , Dietary supplement , Drug effects , Motor activity , Swimming , Vaccination , Adjuvants , Adjuvants , Aluminum hydroxide , Animals , Behavior , Depression , Dietary supplements , Female , Human papillomavirus recombinant vaccine quadrivalent, types 6, 11, 16, 18 , Mice , Mice , Motor activity , Phospholipids , Swimming , Vaccination , Aluminum , Autoimmunity , Behavior , Depression , Gardasil
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