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Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
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Garzón-Ospina, Diego
Forero-Rodríguez, Johanna
Patarroyo, Manuel A.
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Fecha
2015
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Elsevier
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Resumen
Abstract
Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V.
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Keywords
Allele , dna , Dna polymorphism , Dna sequence , Gene mutation , Genetic variability , Merozoite , Microbial gene , Multigene family , Natural selection , Nonhuman , Plasmodium vivax , Priority journal , Signal transduction , Biology , Genetic polymorphism , Genetic selection , Genetic variation , Genetics , Host parasite interaction , Metabolism , Phylogeny , Physiology , Plasmodium vivax , Plasmodium parasites , Plasmodium vivax , Protozoal protein , Computational biology , Genetic variation , Host-parasite interactions , Phylogeny , Plasmodium vivax , Polymorphism , Protozoan proteins , Selection , Sequence analysis , Allele-specific response , Anti-malarial vaccine , Natural selection signal , Plasmodium vivax
